Cefoperazone

Drug #844

Cefoperazone is a third generation semisynthetic,ß lactamase resistant cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporic acid and are closely related to penicillins in structure. Cephalosporins have a six membered sulfur containing ring adjoining a ß lactam ring. Cefoperazone is a broad spectrum antibiotic effective against a large range of aerobic and anaerobic gram positive and gram negative bacteria. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Cefoperazone (Na) is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.

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Primary Characteristics

Cefoperazone is also known as Cefoperazone (Na).

It is of Semi Synthetic origin and belongs to Cephem Carboxylate.

It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Cephalosporin-3rd Gen pharmacological group.

Molecular Weight: 667.7 · Solubility in Water: freely · Solubility in Alcohol: soluble · Non-proprietary name: Cefoperazone (Na).

Pharmacokinetics

Distribution: Cefoperazone has a plasma protein binding is 8 2-93%.

Elimination: plasma half-life is 2 hr, renal excretion is 30%.

Indications

Cefoperazone is primarily indicated in conditions like Bone and joint infection, Pelvic inflammatory disease, Peritonitis, Respiratory tract infections, Septicaemia, Skin infections, Urinary tract infection.

Contraindications

Cefoperazone is contraindicated in conditions like Hypersensitivity to any component of product.

Dosage

Cefoperazone's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
1.5 g	1.5 g	Every 12h	IV/IM
Paediatric Dosage (20kg)
62.5 mg/kg	62.5 mg/kg	Every 12h	Intra Muscular	-
62.5 mg/kg	62.5 mg/kg	Every 12h	Intra Venous	-
Neonatal Dosage (3kg)
62.5 mg/kg	62.5 mg/kg	Every 12h	Intra Muscular	-
62.5 mg/kg	62.5 mg/kg	Every 12h	Intra Venous	-

Drug Interactions

Unknown3 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Cefoperazone in overdosage may give rise to further complications which include Anemia , Gi bleeding , Leucopenia, Hemolytic anemia , Bleeding , Lymphocytosis , Bone marrow depression .

Cefoperazone is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Anorexia , Chills, Dizziness, Dyspnea, Fever, Paresthesias, Skin rashes, Urticaria.

Warnings / Precautions

Cefoparazone should be used with caution in patients with impaired kidney or liver function. Appropriate measure should be taken if secondary infection occurs.

Available Brands

Click on a strength to view available brands.

Single Ingredient

1 gm 2 mg

Inj

1 g 2 g 250 mg 500 mg

Inj-IM

1 gm

Multi-Ingredient Combinations

Inj

1 g 125 mg 250 mg 500 mg

Inj-IV

500 mg

Storage Conditions

Cefoperazone should be stored Dry Powder for Inj.

Drug Classification

1.6.2.1.3 — Cephalosporins