DrugInfoSys

Bromazepam

Drug #823

Bromazepam is a benzodiazepine with general properties similar to those of diazepam. Bromazepam is used in the treatment of anxiety and as a hypnotic.

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Primary Characteristics

It is of Synthetic origin and belongs to Benzodiazepine.

It belongs to Chloride Channel Potentiater (GABA operated) pharmacological group on the basis of mechanism of action and also classified in Benzodiazepine pharmacological group. It is also classified under Sedatives and Hypnotics .

Molecular Weight: 316.2 · Solubility in Water: insoluble · Solubility in Alcohol: sparingly · Non-proprietary name: Bromazepam.

Molecular structure of Bromazepam

Pharmacokinetics

Distribution: Bromazepam has a volume of distribution is 50 litre. plasma protein binding is 70%.

Elimination: it is metabolised via Hepatic.

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Indications

Bromazepam is primarily indicated in conditions like Acute tension, Agitation, Anxiety, Bloating diarrohea, Dysmenorrhoea, Dyspnea, Epigastric pain, Hypertension, Hyperventilation, Insomnia, Irritable bladder, Irritable bowel syndrome, Pseudoangina pectoris, Spasm, Tachycardia.

Contraindications

Bromazepam is contraindicated in conditions like Respiratory insufficiency, Hepatic insufficiency, Sleep apnea syndrome, Hypersensitivity.

Dosage

Bromazepam's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
2.25 mg2.25 mgEvery 12hPOFor 8-12 Weeks. Frequency may increased to 3 times/day.
17 mg17 mgEvery 12hPOGiven for Anxiety
Paediatric Dosage (20kg)
0 – 0———Not Recommended in this Age Group
Neonatal Dosage (3kg)
0 – 0——Not recommended in this age group

Drug Interactions

Unknown10 interactions
3 interactions
Major1 interaction
Moderate1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Bromazepam in overdosage may give rise to further complications which include Psychosis .

Bromazepam is known to cause more or less tolerable side effects which are usually transient. These include Agitation , Ataxia, Confusion, Delusion, Dizziness, Drowsiness, Fatigue, Hallucination , Headache, Irritability, Muscle weakness, Nightmares, Numbed emotions, Reduced alertness.

Warnings / Precautions

It should be used with caution in patients with respiratory disease, muscle weakness, history of drug or alcohol abuse, marked personality disorders, in pregnancy and breast feeding, reduce the dose in elderly and debilitated patients. Avoid prolonged use and abrupt withdrawal thereafter. It should be used with extreme caution in patients with renal and hepatic impairment. It should be injected intravenously slowly, not to be mixed with other solution.It is not recommended for use in depressive disorder,psychosis.

Available Brands

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Single Ingredient

Tabs
1.5 mg3 mg6 mg

Storage Conditions

Bromazepam should be stored Tabs.

Drug Classification

  1. 1.24.3 — Drugs used in anxiety and sleep disorders

Manufacturers