Brinzolamide
Brinzolamide is used topically to reduce intra-ocular pressure in the management of glucoma and ocular hypertension.
Primary Characteristics
It is of Synthetic origin and belongs to Sulphonamide.
It is classified in Antiglaucoma pharmacological group. It is also classified under Opthalmic Products .
Molecular Weight: 383.5 · Solubility in Water: insoluble · Solubility in Alcohol: soluble · Non-proprietary name: Brinzolamide · pH: 7.5.
Pharmacokinetics
Distribution: Brinzolamide has a plasma protein binding is 60%.
Elimination: plasma half-life is 111days, renal excretion is 60%.
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Indications
Brinzolamide is primarily indicated in conditions like Glucoma, Ocular hypertension.
Contraindications
Brinzolamide is contraindicated in conditions like Hypersensitivity to the drug.
Dosage
Brinzolamide's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0.5 mg | 0.5 mg | Every 8h | Ophthalmic | Or 1% drops. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
None recorded.
Side Effects
Brinzolamide is known to cause more or less tolerable side effects which are usually transient. These include Blepharitis , Blurred vision, Dermatitis, Dizziness, Dryness of eye, Eye discharge, Eye Pain , Headache, Itching, Rhinitis , Taste disturbances, Urticaria.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.21.4.4 — Carbonic anhydrase inhibitors