Bromelains
Bromelains is a mixture of proteolytic enzymes i.e., any of the several cysteine endopeptidases that catalyzes the cleavage of proteins on the carboxyl side of alanine, glycine, lysine and tyrosine bonds. Different forms are derived from the fruit (fruit bromelain) and stem (stem bromelain) of the pineapple plant. The enzyme is administered orally as an anti-inflammatory agent.
Primary Characteristics
It is of Natural origin and belongs to Proteolytic Enzyme .
It is also classified under Analgesics and Anti-inflammatory Agents .
Solubility in Water: null · Solubility in Alcohol: null · Non-proprietary name: Bromelain.
Pharmacokinetics
Distribution: Bromelains has a volume of distribution is . plasma protein binding is .
Elimination: it is metabolised via , plasma half-life is , renal excretion is .
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Indications
Bromelains is primarily indicated in conditions like Digestive problems, Edema, Oedema, Soft tissue inflammation, Trauma.
Contraindications
Bromelains is contraindicated in conditions like Coagulation disorder.
Dosage
Bromelains's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 10.5 mg | 10.5 mg | Every 12h | PO | For 8-12 weeks. Frequency may be increased to 3 times if needed. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
None recorded.
Side Effects
Bromelains is known to cause more or less tolerable side effects which are usually transient. These include Asthma, Diarrhea, Menorrhagia , Nausea, Vomiting .
Warnings / Precautions
Available Brands
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Multi-Ingredient Combinations
Storage Conditions
Drug Classification
- 1.17.11 — Digestive enzymes