Azelaic Acid
Azelaic Acid is a straight chain saturated dicarboxylic acid occuring in rancid oleic acid. It has antibacterial and anti-inflammatory properties. It has cytotoxic effect on malignant or hyperactive melanocytes and has been administered topically and orally in the treatment of malignant melanoma, hyperpigmentation disorders and acne vulgaris.
Primary Characteristics
It is of Semi Synthetic origin and belongs to Dicarboxylic Acid.
It is also classified under Dermatological Products .
Molecular Weight: 188.2 · pKa: 4.550 · Solubility in Water: 2.14g/L · Solubility in Alcohol: null · Non-proprietary name: Azelaic Acid.
Pharmacokinetics
Elimination: plasma half-life is 12 hr.
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Indications
Azelaic Acid is primarily indicated in conditions like Acne vulgaris.
Contraindications
Azelaic Acid is contraindicated in conditions like Hypersensitivity to the drug.
Dosage
Azelaic Acid's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 20 % | 20 % | Every 12h | Topical | - |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | — | Not Recommended in this Age Group |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
None recorded.
Side Effects
Azelaic Acid is known to cause more or less tolerable side effects which are usually transient. These include Burning, Contact dermatitis, Dryness , Hypopigmentation, Itching, Redness, Skin irritation.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.13.5.1 — Antiacne preparations