Anastrazole
Also known as: Anastrozole
Anastrozole is antineoplastic agent, also called as anticancerous drug. Anastrozole is a new selective non-steroidal inhibitor of aromatase. Anastrozole is effective in the treatment of post-menopausal breast cancer in women to slow or stop the growth of abnormal cells, which is not responsive to tamoxifen.
Primary Characteristics
Anastrazole is also known as Anastrozole.
It is of Synthetic origin and belongs to Methylpropiononitrile.
It is classified in Antineoplastic Agent pharmacological group. It is also classified under Chemotherapeutic Regimens .
Molecular Weight: 293.4 · Solubility in Water: 0.5mg/mL · Solubility in Alcohol: null · Non-proprietary name: Anastrazole.
Pharmacokinetics
Absorption: Anastrazole has an oral bioavailability is 50% (±50%).
Distribution: Anastrazole has a plasma protein binding is 44%.
Elimination: it is metabolised via 85%, plasma half-life is 40-50 hr, renal excretion is 11%.
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Indications
Anastrazole is primarily indicated in conditions like Breast cancer.
Anastrazole is also indicated for secondary conditions like Advanced breast cancer in postmenopausal women.
Contraindications
None recorded.
Dosage
Anastrazole's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 5.5 mg | 5.5 mg | Every 24h | PO | |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | — | Not Recommended in this Age Group |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Anastrazole in overdosage may give rise to further complications which include Thrombophlebitis , Leucopenia.
Anastrazole is known to cause more or less tolerable side effects which are usually transient. These include Anorexia , Arthralgia, Asthenia , Diarrhea, Hair thinning, Headache, Nausea, Rashes , Vaginal dryness, Vomiting .
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.8.3 — Hormones and antihormones