Sulbactam

Drug #799

Sulbactam is a beta lactamase inhibitor. It does not have significant antibacterial activity, rather it binds and inactivates ß- lactamases (the family of enzymes hydrolyzes the cyclic amide bond of ß-lactam ring, which result in loss of bactericidal activity), thereby protecting antibiotics that are normally the substrates of these enzymes. Sulbactam is used with penicillins and other ß-lactam antibiotics to protect them from enzymatic inactivation.

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Primary Characteristics

Sulbactam is also known as Sulbactum Trihydrate, Sulbactam (Na).

It is of Synthetic origin and belongs to Penicillanic acid sulphone.

It is classified in Antibacterial pharmacological group.

Molecular Weight: 233.2 · Solubility in Water: freely soluble · Solubility in Alcohol: null · Non-proprietary name: Sulbactam.

Pharmacokinetics

Distribution: Sulbactam has a plasma protein binding is 38%.

Elimination: it is metabolised via 15-25% via liver, plasma half-life is 1-2 hr, renal excretion is 30%.

Indications

Sulbactam is primarily indicated in conditions like Beta lactamase resistant pseudomonas, Gynecological infections, Intra-abdominal infections, Methicillin resistant staphylococci, Skin infections.

Contraindications

Sulbactam is contraindicated in conditions like Hypersensitivity.

Dosage

Sulbactam's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
250 mg	250 mg	Every 6h	PO/IV/IM	In combination with Amoxycillin 250mg
500 mg	500 mg	Every 6h	PO/IV/IM	In combination with Ampicillin 1g.
Paediatric Dosage (20kg)
16.66 mg/kg	16.66 mg/kg	Every 8h	Intramuscular	For 5---14 days
16.66 mg/kg	16.66 mg/kg	Every 8h	Intravenous	For 5--14 days
1.875 mg/kg	1.875 mg/kg	Every 12h	Oral
Neonatal Dosage (3kg)
25 mg/kg	25 mg/kg	Every 12h	Intavenous	For 5---14 days
25 mg/kg	25 mg/kg	Every 12h	Intramuscular	For 5----14 days

Drug Interactions

Unknown2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Sulbactam in overdosage may give rise to further complications which include Bone marrow depression , Exfoliative dermatitis .

Sulbactam produces potentially life-threatening effects which include Anaphylaxis . Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Sulbactam are Seizures.

Sulbactam is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Dysuria, Epistaxis, Fatigue, Glossitis, Headache, Malaise, Urinary retention, Urinary RetentionX.

Warnings / Precautions

Sulbactam should be used with caution in patients with illnesses or any allergy especially to penicillin or other antibiotics. In diabetic patients, this can affect the results of clinitest tablets. This may interfere with oral contraceptives, if using oral contraceptives discuss with doctor alternate birth control methods to use, while using this medication. It should be used only if clearly needed during pregnancy or lactation.

Interference in Pathology

Sulbactam may interfere in the diagnosis of False +ve Test for Urinary Aminoacids .

Available Brands

Click on a strength to view available brands.

Single Ingredient

Inj

1 g 500 mg

Multi-Ingredient Combinations

Inj

0.5 gm 1 g 1 gm 100 mg 125 mg 250 mg 3000 mg 375 mg 500 mg 750 mg

Inj-IV

Susp

Susp

Tabs

Storage Conditions

Sulbactam should be stored Inj.

Drug Classification

1.6.2.1.1 — Penicillins