Benorylate

Also known as: Fenasprate

Drug #79

Benorylate is an aspirin-paracetamol ester with analgesic, anti-inflammatory, and antipyretic properties. Benorylate is used in the treatment of mild-moderate pain, fever and rheumatoid arthritis. This durg has been discontinued.

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Primary Characteristics

Benorylate is also known as Fenasprate.

It is of Synthetic origin and belongs to Phenylbenzoate.

It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action. It is also classified under Analgesics and Anti-inflammatory Agents .

Molecular Weight: 313.3 · Solubility in Water: practically insoluble · Solubility in Alcohol: 1 in 88 · Non-proprietary name: Benorylate.

Pharmacokinetics

Absorption: Benorylate has an oral bioavailability is 100%.

Elimination: it is metabolised via complete by liver and blood, plasma half-life is 2-10 min, renal excretion is 85%.

Indications

Benorylate is primarily indicated in conditions like Dysmenorrhoea, Mild to moderate pain, Musculoskeletal disorders, Nausea and vomiting (palliative care), Osteoarthritis, Painful musculoskeletal conditions, Rheumatoid arthritis.

Contraindications

Benorylate is contraindicated in conditions like Peptic ulcer.

Dosage

Benorylate's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
85.7 mg/kg	85.7 mg/kg	Every 8h	PO	-
Paediatric Dosage (20kg)
0 – 0	—	—		Should not be used under 12 years
Neonatal Dosage (3kg)
0 – 0	—	—		Notrecommended in this age group

Drug Interactions

Unknown11 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Benorylate in overdosage may give rise to further complications which include Hearing loss , Toxic hepatitis , Salicylism.

Benorylate is known to cause more or less tolerable side effects which are usually transient. These include Constipation , Diarrhea, Drowsiness, Heart burn, Indigestion , Nausea, Rashes , Vomiting .

Warnings / Precautions

Benorylate should be used with caution in patients with renal or hepatic disease. The drug should not be used in neonates and during pregnancy and lactation, in individuals with known hypersensitivity to aspirin (including those with asthma, hemophilia, and similar coagulation disorders) or to acetaminophen.

Available Brands

None recorded.

Storage Conditions

Benorylate should be stored Tab, Susp.

Drug Classification

1.2.1.3 — Non steroidal anti-inflammatory drugs (NSAIDs)