Benoxaprofen

Drug #80

Benoxaprofen is NSAID structurall yrelated to ibuprofen. It was formerly used in rheumatoid arthritis and osteoarthritis. But due to severe side-effects, it ahs been withdrawn from the market.

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Primary Characteristics

It is of Synthetic origin and belongs to Proprionic Acid.

It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action. It is also classified under Analgesics and Anti-inflammatory Agents .

Molecular Weight: 301.7 · pK_a: 3.5 · Solubility in Water: slight · Solubility in Alcohol: soluble · Non-proprietary name: Benoxaprofen.

Pharmacokinetics

Absorption: Benoxaprofen has an oral bioavailability is 50%.

Distribution: Benoxaprofen has a plasma protein binding is 99.8%.

Elimination: it is metabolised via via liver, plasma half-life is 30-35 hr, renal excretion is major.

Indications

Benoxaprofen is primarily indicated in conditions like Osteoarthritis, Rheumatoid arthritis, Soft tissue disorders.

Contraindications

Benoxaprofen is contraindicated in conditions like Peptic ulcer, Renal diseases, Liver diseases.

Dosage

Benoxaprofen's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
4.28 mg/kg	4.28 mg/kg	Every 12h	PO	-
Paediatric Dosage (20kg)
0 – 0	—	—	—	Not Recommended in this Age Group
Neonatal Dosage (3kg)
0 – 0	—	—		Not used in this age group

Drug Interactions

None recorded.

Side Effects

Benoxaprofen in overdosage may give rise to further complications which include Stevens johnson syndrome , Epidermal necrolysis .

Benoxaprofen produces potentially life-threatening effects which include Obstructive Jaundice . Careful monitoring is needed with proper medical management.

Benoxaprofen is known to cause more or less tolerable side effects which are usually transient. These include Burning, Itching, Photosensitivity, Redness, Subepidermal cysts .

Warnings / Precautions

Donot use on broken or secondarly infected skin, during pregnancy and breast feeding. Not to apply in face, prevent contact with eyes.

Available Brands

None recorded.

Storage Conditions

Benoxaprofen should be stored Tab.

Drug Classification

1.2.1.3 — Non steroidal anti-inflammatory drugs (NSAIDs)