Xipamide

Drug #758

Xipamide is a diuretic and antihypertensive agent. Xipamide is a similar to frusemide but slower onset and longer duration of action. Chemically Xipamide is 5-(aminosulfony)-4-chloro-N (2, 6-dimethylphenyl)-2-hydroxybenzamide. Xipamide is used in control of high blood pressure and in the treatment of fluid over load.

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Primary Characteristics

It is of Synthetic origin and belongs to Sulphonamide.

It belongs to NaCl cotransport inhibitor pharmacological group on the basis of mechanism of action and also classified in Diuretic Thiazide pharmacological group.

Molecular Weight: 354.8 · pK_a: 4.8, 10.0 · Solubility in Water: Insoluble · Solubility in Alcohol: 1:10-30 · Non-proprietary name: Xipamide.

Pharmacokinetics

Absorption: Xipamide has an oral bioavailability is 73%.

Distribution: Xipamide has a volume of distribution is 15 - 21 litre. plasma protein binding is 99 %.

Elimination: plasma half-life is 5.0 hr.

Indications

Xipamide is primarily indicated in conditions like Edema, Hypertension, Left ventricular failure, Oedema.

Contraindications

None recorded.

Dosage

Xipamide's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.286 mg/kg	0.286 mg/kg	Every 24h	PO	-
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Xipamide in overdosage may give rise to further complications which include Dizziness , Nocturia , Vertigo .

Xipamide produces potentially life-threatening effects which include Hypokalemia. Careful monitoring is needed with proper medical management.

Warnings / Precautions

Xipamide should be used with caution in patients with diabetes, kidney or liver disease or any drug allergy. Caution must be observed when eating large amounts of food high in potassium such as bananas, baked potatoes, raisins, cooked spinach and other foods. Alcoholic beverages may increase the effects of this drug, causing dizziness or lightheadedness, so limit alcohol intake. It should be used with caution while engaging in activities requiring alertness. This drug changes fluid balance, cause dizziness, if change from a lying to a standing position too rapidly, avoid this by sitting up a few minutes before rising. It should be used with caution during pregnancy or lactation.

Available Brands

None recorded.

Storage Conditions

Xipamide should be stored Tab.

Drug Classification

1.16.1 — Thiazide and related diuretics