Xamoterol (Fumarate)
Xamoterol (Fumarate) is a partial beta 1-adrenergic receptor agonist. It stimulates the force and rate of heart contraction. Xamoterol (Fumarate) is used to improve heart efficiency in patient with mild heart failure.
Primary Characteristics
It is of Synthetic origin and belongs to Carboxamide.
It belongs to Beta-1 adrenergic partial agonist pharmacological group on the basis of mechanism of action and also classified in Cardiac Insufficency pharmacological group.
Molecular Weight: 794 · pKa: 8.2 · Solubility in Water: 1 in 20 · Solubility in Alcohol: 1 in 5000 · Non-proprietary name: Xamoterol (Fumarate).
Pharmacokinetics
Absorption: Xamoterol (Fumarate) has an oral bioavailability is 9%.
Distribution: Xamoterol (Fumarate) has a volume of distribution is 0.64 l/kg. plasma protein binding is 3 %.
Elimination: it is metabolised via Hepatic, plasma half-life is 16 hr, renal excretion is extensive.
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Indications
Xamoterol (Fumarate) is primarily indicated in conditions like Heart failure.
Contraindications
None recorded.
Dosage
Xamoterol (Fumarate)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 2.857 mg/kg | 2.857 mg/kg | Every 12h | PO | - |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Xamoterol (Fumarate) produces potentially life-threatening effects which include Hypotension, Bronchospasm . Careful monitoring is needed with proper medical management.
Xamoterol (Fumarate) is known to cause more or less tolerable side effects which are usually transient. These include Dizziness, Headache, Muscle cramps, Palpitation, Rashes .
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.12.4 — Drugs used in heart failure