DrugInfoSys

Warfarin (Na)

Also known as: Warfarin

Drug #756

Warfarin (Na) is a synthetic, oral coumarin prothrombopenic anticoagulant agent. Chemically Warfarin (Na) is identified as 3-(a-acetonylbenzyl)-4-hydroxycoumarin sodium. Warfarin (Na) is also the active ingredient in various rodenticides and insecticides. Warfarin is a racemic mixture of roughly equal amounts of two active isomers; the S-form is roughly 5 times as potent as a vitamin K antagonist than the R-form. Clinically, warfarin is used to prevent and treat thromboembolic disease. Some clinicians believe that warfarin, despite its higher associated risk of bleeding, is preferable to aspirin for prevention of stroke in patients with nonvalvular atrial fibrillation. Warfarin is currently being actively studied to determine its role in acute myocardial infarction. Warfarin was originally approved by the FDA in 1954.

Primary Characteristics

Warfarin (Na) is also known as Warfarin.

It belongs to Coumarin.

It belongs to Epoxide Reductase inhibitor pharmacological group on the basis of mechanism of action and also classified in Anticoagulants pharmacological group.

Molecular Weight: 330.3 · pKa: 5.0 · Solubility in Water: > 1 in 1 · Solubility in Alcohol: > 1 in 1 · Non-proprietary name: Warfarin (Na) · pH: 8.1 · Isotonic value: 6.1.

Molecular structure of Warfarin (Na)

Pharmacokinetics

Absorption: Warfarin (Na) has an oral bioavailability is 96.5% (±1.5%), pre-systemic (first-pass) metabolism accounts for 45.5% (±4.5%).

Distribution: Warfarin (Na) has a volume of distribution is 0.08 - 0.27 l/kg. plasma protein binding is 97 - 99.5 %.

Elimination: it is metabolised via Hepatic, plasma half-life is 10 - 45 hr, renal excretion is <2%.

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Indications

Contraindications

Warfarin (Na) is contraindicated in conditions like Hyperthyroidism, Haemorrhage.

Dosage

Warfarin (Na)'s dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
3.5 mg/day3.5 mg/dayIMfor 2 to 4 days, then the dose may be adjusted depending on patients conditions and results of routine blood tests.
6 mg6 mgEvery 24hPOMaintenance, As Required
10 mg10 mgEvery 24hPOInitially for 2-5 days
Paediatric Dosage (20kg)
0.15 mg/kg0.15 mg/kgEvery 24hOral Maintenance
0.4 mg/kg0.4 mg/kgEvery 24hOral Loading
Neonatal Dosage (3kg)
0.15 mg/kg0.15 mg/kgEvery 24hOral Maintenance
0.4 mg/kg0.4 mg/kgEvery 24hOral Loading

Drug Interactions

Unknown74 interactions
64 interactions
(Sequence important)1 interaction
Major16 interactions
Minor1 interaction
Moderate35 interactions
Moderate (Sequence important)7 interactions
N/A1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Warfarin (Na) in overdosage may give rise to further complications which include Alopecia , Purple toes .

Warfarin (Na) produces potentially life-threatening effects which include Hemorrhage . Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Warfarin (Na) are Cerebral hemorrhage, GI hemorrhage.

Warfarin (Na) is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Fever, Nausea and vomiting.

Warnings / Precautions

Warfarin should be used with caution in patients with ulcers, unusual menstrual periods, diabetes, liver or kidney disease, high blood pressure, arthritis, thyroid problems, all recent infections, if have had recent surgery or of drug and food allergies. Consult the doctor or pharmacist before switching warfarin products. If patient have an illness that causes vomiting, diarrhea or fever for more than a few days, contact the doctor as these problems can change the effect of warfarin. Limit consumption of alcoholic beverages. In the event of an accidental overdose of warfarin, contact the doctor, poison control center or nearest hospital emergency department immediately. Avoid sudden changes in dietary habits, when use warfarin. Avoid ingesting unusual increases or decreases of foods high in Vitamin K (e.g.liver, cauliflower, cabbage, spinach and other green leafy vegetables, green tea, certain vegetables, cheeses and certain vitamin supplements). It is best to avoid strictly vegetarian diets that consist of foods high in vitamin K.While taking warfarin, be extra careful to avoid injuries, because this medication can cause heavy bleeding. Use an electric razor and be careful while brushing teeth. Warfarin should not be used during pregnancy. Use with caution during lactation.

Available Brands

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Single Ingredient

Multi-Ingredient Combinations

Inj

Storage Conditions

Warfarin (Na) should be stored Tab, Inj.

Drug Classification

  1. 1.10.2Anticoagulants/Platelet deaggregators

Manufacturers