Warfarin (Na)
Also known as: Warfarin
Warfarin (Na) is a synthetic, oral coumarin prothrombopenic anticoagulant agent. Chemically Warfarin (Na) is identified as 3-(a-acetonylbenzyl)-4-hydroxycoumarin sodium. Warfarin (Na) is also the active ingredient in various rodenticides and insecticides. Warfarin is a racemic mixture of roughly equal amounts of two active isomers; the S-form is roughly 5 times as potent as a vitamin K antagonist than the R-form. Clinically, warfarin is used to prevent and treat thromboembolic disease. Some clinicians believe that warfarin, despite its higher associated risk of bleeding, is preferable to aspirin for prevention of stroke in patients with nonvalvular atrial fibrillation. Warfarin is currently being actively studied to determine its role in acute myocardial infarction. Warfarin was originally approved by the FDA in 1954.
Primary Characteristics
Warfarin (Na) is also known as Warfarin.
It belongs to Coumarin.
It belongs to Epoxide Reductase inhibitor pharmacological group on the basis of mechanism of action and also classified in Anticoagulants pharmacological group.
Molecular Weight: 330.3 · pKa: 5.0 · Solubility in Water: > 1 in 1 · Solubility in Alcohol: > 1 in 1 · Non-proprietary name: Warfarin (Na) · pH: 8.1 · Isotonic value: 6.1.

Pharmacokinetics
Absorption: Warfarin (Na) has an oral bioavailability is 96.5% (±1.5%), pre-systemic (first-pass) metabolism accounts for 45.5% (±4.5%).
Distribution: Warfarin (Na) has a volume of distribution is 0.08 - 0.27 l/kg. plasma protein binding is 97 - 99.5 %.
Elimination: it is metabolised via Hepatic, plasma half-life is 10 - 45 hr, renal excretion is <2%.
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Indications
Warfarin (Na) is primarily indicated in conditions like Anticoagulant, Atrial fibrillation, Deep vein thrombosis, Ischaemic heart disease, Myocardial infarction, Prophylaxis after insertion of prosthetic heart valve, Prophylaxis and treatment of venous thrombosis and pulmonary embolism, Prophylaxis of embolisation in rheumatic heart disease and atrial fibrillation, Systemic embolism, Uncomplicated premature labor, Valvular heart disease.
Contraindications
Warfarin (Na) is contraindicated in conditions like Hyperthyroidism, Haemorrhage.
Dosage
Warfarin (Na)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 3.5 mg/day | 3.5 mg/day | — | IM | for 2 to 4 days, then the dose may be adjusted depending on patients conditions and results of routine blood tests. |
| 6 mg | 6 mg | Every 24h | PO | Maintenance, As Required |
| 10 mg | 10 mg | Every 24h | PO | Initially for 2-5 days |
| Paediatric Dosage (20kg) | ||||
| 0.15 mg/kg | 0.15 mg/kg | Every 24h | Oral | Maintenance |
| 0.4 mg/kg | 0.4 mg/kg | Every 24h | Oral | Loading |
| Neonatal Dosage (3kg) | ||||
| 0.15 mg/kg | 0.15 mg/kg | Every 24h | Oral | Maintenance |
| 0.4 mg/kg | 0.4 mg/kg | Every 24h | Oral | Loading |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Warfarin (Na) in overdosage may give rise to further complications which include Alopecia , Purple toes .
Warfarin (Na) produces potentially life-threatening effects which include Hemorrhage . Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Warfarin (Na) are Cerebral hemorrhage, GI hemorrhage.
Warfarin (Na) is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Fever, Nausea and vomiting.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.10.2 — Anticoagulants/Platelet deaggregators