DrugInfoSys

Vitamin K

Drug #755

Vitamin K is a fat soluble substance. Chemically Vitamin K is 2-methyl-1, 4-napthoquinone. It plays an important role in blood clotting, Vitamin K is essential cofactor in the hepatic synthesis of prothrombin and other blood clotting factors. Vitamin K is used in the treatment and prevention of hemorrhages and spontaneous bleeding associated with vitamin K deficiency or caused by some anticoaggulants (e.g coumarin). The dietary requirement of vitamin K is low because the vitamin is additionally synthesized by the bacteria that colonize the human intestine. Two natural forms of vitamin K exist: Vitamin K1, also called as phytonadione is found in many foods especially leafy green vegetables such as cabbage and spinach and also present in liver, cow's milk, egg yolk and some cereals; Viatmin K 2, also known as menaquinone is synthesized by intestinal bacteria.

Primary Characteristics

It is of Natural origin and belongs to Naphthoquinone.

It belongs to Nutrients and Vitamins pharmacological group on the basis of mechanism of action and also classified in Coagulant pharmacological group.

Molecular Weight: 450.7 · pKa: not ionizable · Solubility in Water: < 1 in 10000 · Solubility in Alcohol: 1 in 70 · Non-proprietary name: Vitamin K.

Molecular structure of Vitamin K

Pharmacokinetics

Absorption: Vitamin K has an oral bioavailability is 36.5% (±26.5%).

Distribution: Vitamin K has a volume of distribution is 3.51. plasma protein binding is extensive.

Elimination: plasma half-life is 2.2 hr.

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Indications

Vitamin K is primarily indicated in conditions like Haemorrhage, Over dosage of anticoagulants, Vitamin deficiency.

Contraindications

None recorded.

Dosage

Vitamin K's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
11.25 mg11.25 mgIV,IM,SCAs required
15 mg15 mgEvery 24hPO
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown8 interactions
Moderate1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Vitamin K in overdosage may give rise to further complications which include Bronchospasm , Chest tightness , Flushing , Hematoma, Sweating .

Vitamin K produces potentially life-threatening effects which include Anaphylactic reactions. Careful monitoring is needed with proper medical management.

Warnings / Precautions

Vitamin K should be used with caution in patients with any pre-existing blood disorder or allergy. It should be used as directed during pregnancy or lactation.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Tabs

Multi-Ingredient Combinations

Storage Conditions

Vitamin K should be stored Inj.

Drug Classification

  1. 1.27Vitamins, minerals, tonics, and other susbstances

Manufacturers

Manufacturers of Vitamin K in Pakistan: