Vitamin K
Vitamin K is a fat soluble substance. Chemically Vitamin K is 2-methyl-1, 4-napthoquinone. It plays an important role in blood clotting, Vitamin K is essential cofactor in the hepatic synthesis of prothrombin and other blood clotting factors. Vitamin K is used in the treatment and prevention of hemorrhages and spontaneous bleeding associated with vitamin K deficiency or caused by some anticoaggulants (e.g coumarin). The dietary requirement of vitamin K is low because the vitamin is additionally synthesized by the bacteria that colonize the human intestine. Two natural forms of vitamin K exist: Vitamin K1, also called as phytonadione is found in many foods especially leafy green vegetables such as cabbage and spinach and also present in liver, cow's milk, egg yolk and some cereals; Viatmin K 2, also known as menaquinone is synthesized by intestinal bacteria.
Primary Characteristics
It is of Natural origin and belongs to Naphthoquinone.
It belongs to Nutrients and Vitamins pharmacological group on the basis of mechanism of action and also classified in Coagulant pharmacological group.
Molecular Weight: 450.7 · pKa: not ionizable · Solubility in Water: < 1 in 10000 · Solubility in Alcohol: 1 in 70 · Non-proprietary name: Vitamin K.

Pharmacokinetics
Absorption: Vitamin K has an oral bioavailability is 36.5% (±26.5%).
Distribution: Vitamin K has a volume of distribution is 3.51. plasma protein binding is extensive.
Elimination: plasma half-life is 2.2 hr.
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Indications
Vitamin K is primarily indicated in conditions like Haemorrhage, Over dosage of anticoagulants, Vitamin deficiency.
Contraindications
None recorded.
Dosage
Vitamin K's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 11.25 mg | 11.25 mg | — | IV,IM,SC | As required |
| 15 mg | 15 mg | Every 24h | PO | |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Vitamin K in overdosage may give rise to further complications which include Bronchospasm , Chest tightness , Flushing , Hematoma, Sweating .
Vitamin K produces potentially life-threatening effects which include Anaphylactic reactions. Careful monitoring is needed with proper medical management.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.27 — Vitamins, minerals, tonics, and other susbstances
Manufacturers
Manufacturers of Vitamin K in Pakistan: