Vidarabine (Monohydrate)

Also known as: Ara-A

Drug #751

Vidarabine (Monohydrate) is adenosine analog. Vidarabine (Monohydrate) is antiviral agent. Vidarabine (Monohydrate) is active against herpes simplex viruses, varicella zoster virus and cytomegalovirus.

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Primary Characteristics

Vidarabine (Monohydrate) is also known as Ara-A.

It is of Semi Synthetic origin and belongs to Arabinofuranosyladenine.

It belongs to DNA polymerase inhibitor pharmacological group on the basis of mechanism of action. It is also classified under Antiviral Agents .

Molecular Weight: 285.3 · Solubility in Water: 1 in 2000 · Non-proprietary name: Vidarabine (Monohydrate).

Molecular structure of Vidarabine (Monohydrate)

Pharmacokinetics

Elimination: plasma half-life is 3.3 hr, renal excretion is 1 - 3 % (unchanged)40-53%(metabolites).

Indications

Vidarabine (Monohydrate) is primarily indicated in conditions like Herpes simplex infections, Herpes simplex keratitis, Varicella zoster infections.

Contraindications

Vidarabine (Monohydrate) is contraindicated in conditions like Hypersensitivity to the drug.

Dosage

Vidarabine (Monohydrate)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
1.041 mg/kg.hr	1.041 mg/kg.hr	Every 24h	IV Inf	For 12 Hours in a Day
3 %	3 %	Every 4.8h	Ophthalmic	As Required
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown4 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Vidarabine (Monohydrate) in overdosage may give rise to further complications which include Megaloblastic anemia.

The signs and symptoms that are produced after acute overdosage of Vidarabine (Monohydrate) are Thrombocytopenia , Hematopoietic depression.

Vidarabine (Monohydrate) is known to cause more or less tolerable side effects which are usually transient. These include Anorexia , Ataxia, Confusion, Diarrhea, Dizziness, Hallucination , Nausea and vomiting, Phosis , Tremor.

Warnings / Precautions

Vidarabine should be used only if clearly needed during pregnancy or lactation. It should be used with caution in patients with any eye problem or allergy, especially to any antibiotic.

Available Brands

None recorded.

Storage Conditions

Vidarabine (Monohydrate) should be stored Eye Oint.

Drug Classification

1.6.5.1 — Herpes and cytomegalovirus infection
2.21.1.2 — Antivirals