Vigabatrin
Also known as: Gamma Vinyl Aminobutyric Acid
Vigabatrin is anticonvulsant agent. Vigabatrin is analogue of GABA (gamma amino-butyric acid). GABA is an inhibitory neurotransmitter, which is thought to be deficient in epilepsy, and able to stabilise discharges from epileptic foci. Vigabatrin is used in treatment of epilepsy, especially when not controlled by other drugs.
Primary Characteristics
Vigabatrin is also known as Gamma Vinyl Aminobutyric Acid.
It is of Synthetic origin and belongs to Aminohexanoic Acid.
It belongs to Gaba transaminase inhibitor pharmacological group on the basis of mechanism of action and also classified in Antineoplastic Agent pharmacological group. It is also classified under Psychotherapeutic Drugs .
Molecular Weight: 129.6 · pKa: 4.02, 9.72 · Solubility in Water: 1 in 3 · Solubility in Alcohol: 1 in 10 · Non-proprietary name: Vigabatrin.
Pharmacokinetics
Absorption: Vigabatrin has an oral bioavailability is 85% (±5%), pre-systemic (first-pass) metabolism accounts for 0.5% (±0.5%).
Distribution: Vigabatrin has a volume of distribution is 0.85 l/kg. plasma protein binding is negligible.
Elimination: plasma half-life is 7-8 hr.
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Indications
Vigabatrin is primarily indicated in conditions like Epilepsy, Infantile spasms.
Vigabatrin is also indicated for secondary conditions like Iron deficiency anaemia.
Contraindications
Vigabatrin is contraindicated in conditions like Ventricular arrhythmias resistant to other treatment.
Dosage
Vigabatrin's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 39.286 mg/kg | 39.286 mg/kg | Every 24h | PO | - |
| Paediatric Dosage (20kg) | ||||
| 35 mg/kg | 35 mg/kg | Every 12h | Oral | - |
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
The signs and symptoms that are produced after acute overdosage of Vigabatrin are Coma, Vertigo , Unconsciousness, Tremor.
Vigabatrin is known to cause more or less tolerable side effects which are usually transient. These include Ataxia, Confusion, Depression, Diplopia, Dizziness, Fatigue, Headache, Irritability, Nervousness, Psychosis, SomnolenceX.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.5 — Anticonvulsants and Antiepileptics
Manufacturers
Manufacturers of Vigabatrin in Pakistan: