Vecuronium (Br)
Vecuronium is a skeletal muscle relaxant. Vecuronium (Br) is a competitive neuromuscular blocking agent. itinhibits the transmission at the neuromuscualr junction. During the 16th century, European explorers found that natives of the Amazon Basin of South America were using an arrow poison that produced death by skeletal muscle paralysis. This poison later became the subject of intense investigation. Curare, the active crude materal, formed the basis for some of the earliest scientific studies in pharmacology. The active principle curare from tubocurarine and its synthetic derivative have had a tremendous influence on the practice of anesthesia and surgrey and have been useful also in defining normal neuromuscular physiologic mechanisms.
Primary Characteristics
It is of Synthetic origin and belongs to Steroid.
It belongs to Cholinergic nicotinic antagonist pharmacological group on the basis of mechanism of action and also classified in Neuromuscular Blocking Agent, Nondepolarizing pharmacological group. It is also classified under Muscle Relaxants .
Molecular Weight: 637.7 · pKa: 8.97 · Solubility in Water: 1 in 110 · Solubility in Alcohol: 1 in 44 · Non-proprietary name: Vecuronium (Br).
Pharmacokinetics
Absorption: Vecuronium (Br) has an oral bioavailability is 0.5% (±0.5%).
Distribution: Vecuronium (Br) has a volume of distribution is 0.3 l/kg. plasma protein binding is < 91 %.
Elimination: plasma half-life is 71 min.
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Indications
Vecuronium (Br) is primarily indicated in conditions like Muscle relaxation (intermediate duration) for surgery or intubation, Surgical neuromuscular blocker.
Contraindications
Vecuronium (Br) is contraindicated in conditions like Obstructive airway disease, GI motality disorder.
Dosage
Vecuronium (Br)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 90 ug/kg | 90 ug/kg | — | IV | Initially for Once |
| 65 ug/kg.min | 65 ug/kg.min | — | IV Inf | Maintenance, As Required |
| Paediatric Dosage (20kg) | ||||
| 40 ug/kg | 40 ug/kg | — | Intravenous | Maintenance,as required |
| 90 ug/kg | 90 ug/kg | — | Intravenous | Initial |
| 65 ug/kg.hr | 65 ug/kg.hr | — | IV Infusion | As required |
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Vecuronium (Br) in overdosage may give rise to further complications which include Bronchospasm , Cardiac arrhythmias, Urticaria .
The signs and symptoms that are produced after acute overdosage of Vecuronium (Br) are Reduction in Prothrombin time, Reduction in partial thromboplastin.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.20 — Muscle relaxants and cholinesterase inhibitors