Ursodeoxycholic Acid

Drug #747

Ursodeoxycholic Acid is a secondary bile acid formed in the intestine. Ursodeoxycholic Acid is the 7-ß-hydroxy epimer of chenodiol (chenodeoxycholic acid). Chemically Ursodeoxycholic Acid is identified as 3a, 7ß-dihydroxy-5ß-cholan-24-oic acid. Ursodeoxycholic Acid is choleretic and decreases the concentration of cholesterol in bile. Ursodeoxycholic Acid is used to dissolve cholesterol gallstones, also effective for the treatment of primary biliary cirrhosis.

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Primary Characteristics

It is of Synthetic origin and belongs to Steroid.

It belongs to Bile solubiliser (GI) pharmacological group on the basis of mechanism of action and also classified in Antilipemic Agent pharmacological group.

Molecular Weight: 392.6 · pK_a: 5 · Solubility in Water: almost Insoluble · Solubility in Alcohol: freely soluble · Non-proprietary name: Ursodeoxycholic Acid.

Molecular structure of Ursodeoxycholic Acid

Pharmacokinetics

Absorption: Ursodeoxycholic Acid has an oral bioavailability is 100%, pre-systemic (first-pass) metabolism accounts for 62.5% (±12.5%).

Distribution: Ursodeoxycholic Acid has a plasma protein binding is 96 - 99 %.

Elimination: it is metabolised via Hepatic.

Indications

Ursodeoxycholic Acid is primarily indicated in conditions like Cholestrol gall stones, Dissolution of gallstones, Iron-deficiency anaemia with chronic renal failure.

Contraindications

Ursodeoxycholic Acid is contraindicated in conditions like Calcified gallstones, Non-functioning gallbladders, Pigment gallstone.

Dosage

Ursodeoxycholic Acid's dosage details are as follows:

Dose	Single Dose	Frequency	Route
Adult Dosage
10 mg	10 mg	Every 24h	PO
Paediatric Dosage (20kg)
5 mg/kg	5 mg/kg	Every 24h	Oral
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown1 interaction

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Ursodeoxycholic Acid is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea.

Warnings / Precautions

Ursodeoxycholic acid should not be administered to patients with chronic liver disease, peptic ulcer or inflammatory bowel disease. Its use should be avoided in pregnancy.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Caps

250 mg 500 mg

Storage Conditions

Ursodeoxycholic Acid should be stored Susp.

Drug Classification

1.17.9 — Cholagogues & hepatic preparations

Manufacturers

Manufacturers of Ursodeoxycholic Acid in Pakistan:

AGP CCL Genome Shrooq