DrugInfoSys

Urofollitrophin

Drug #745

Urofollitrophin is a follicle-stimulating hormone, extracted from human post-menopausal urine. It stimulates the ovulation in female and spermatogenesis in male.

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Primary Characteristics

It is of Synthetic origin and belongs to Aminoacid.

It belongs to FSH-agonist pharmacological group on the basis of mechanism of action and also classified in Gonadotrophin pharmacological group. It is also classified under Sex Hormones .

Molecular Weight: 47000 · Solubility in Water: soluble · Non-proprietary name: Urofollitrophin.

Molecular structure of Urofollitrophin

Pharmacokinetics

Elimination: it is metabolised via Hepatic, renal excretion is 6.8 - 10.2 %.

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Indications

Urofollitrophin is primarily indicated in conditions like Induction of ovulation, Polycystic ovary syndrome.

Contraindications

Urofollitrophin is contraindicated in conditions like Ovarian failure, Ovarian dysgenesis, Ovarian cysts.

Dosage

Urofollitrophin's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
112.5 IU112.5 IUEvery 24hIMFollowed by 5000-10,000U 1 day after the last dose.
187.5 IU187.5 IUEvery 24hIM,SCAlone in combination with GnRH.
Paediatric Dosage (20kg)
0 – 0——Not applicable in paeds
Neonatal Dosage (3kg)
0 – 0——Not applicable in this age group

Drug Interactions

None recorded.

Side Effects

Urofollitrophin in overdosage may give rise to further complications which include Hyperstimulation syndrome .

Urofollitrophin produces potentially life-threatening effects which include Electrolyte and volume depletion, Oliguria, Ovarian enlargement, Ascites, Pleural effusion, Acute Renal Failure. Careful monitoring is needed with proper medical management.

Urofollitrophin is known to cause more or less tolerable side effects which are usually transient. These include Breast tenderness, Dry skin, GI disturbance, Hair loss, Headache, Rashes , Urticaria.

Warnings / Precautions

It should only be used by physicians who are thoroughly familiar with infertility problems and their managments. It's use require appropriate monitoring facilitate.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Inj
100 IU50 IU
Inj
75 IU

Storage Conditions

Urofollitrophin should be stored Inj.

Drug Classification

  1. 1.18.6 — Ovulation stimulants

Manufacturers

Manufacturers of Urofollitrophin in Pakistan:

Excel HealthcareGalaxyHiltonObs