Urea (Topical)

Also known as: Carbamide

Drug #744

Urea is formed in the liver through the urea cycle from ammonia. Urea (Topical) is the principal end product of the protein catabolism and constitutes about one half of the total urinary solids. Pharmaceutically, Urea (Topical) is used in creams as an emollient, which soften and moisturize the skin and reduce excess scaling and also used to protect the skin against irritation (chafing, diaper rash).

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Primary Characteristics

Urea (Topical) is also known as Carbamide.

It is of Synthetic origin and belongs to Organic Compound.

It belongs to Dermatological-Moisturiser pharmacological group on the basis of mechanism of action. It is also classified under Dermatological Products .

Molecular Weight: 60.06 · pK_a: 0.2 · Solubility in Water: 1 in 1 · Solubility in Alcohol: 1 in 10-12 · Non-proprietary name: Urea (Topical) · pH: 6.6 · Isotonic value: 1.63.

Pharmacokinetics

None recorded.

Indications

Urea (Topical) is primarily indicated in conditions like Dry skin, Eczema, Onychomycoses, Pruritus, Psoriasis, Skin ulceration, Slack hairy tounge.

Contraindications

Urea (Topical) is contraindicated in conditions like Bacterial infections, Fungal infection, Viral infection.

Dosage

Urea (Topical)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
10 %	10 %	Every 12h	Topical	As Required
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Urea (Topical) is known to cause more or less tolerable side effects which are usually transient. These include Burning, Irritation, Skin eruptions.

Warnings / Precautions

Urea may be used with caution during pregnancy or lactation. It should be used with caution in patients with any skin infection, skin disorder or sensitive to any topical lotions or creams or if have any allergy.

Interference in Pathology

Urea (Topical) may interfere in the diagnosis of Increased level of Blood urea nitrogen (BUN) concentrations.

Available Brands

Click on a strength to view available brands.

Multi-Ingredient Combinations

Cream

10 %w/w

Lotion

3 %w/v

Storage Conditions

Urea (Topical) should be stored Lotion, Cream.

Drug Classification

1.13.5.2 — Others

Manufacturers

Manufacturers of Urea (Topical) in Pakistan:

GSK