Tryptophan

Drug #741

Tryptophan is amino acid. Chemically it is an amino- ß-3-indole propionic acid, existing in proteins. Tryptophan is essential for optimal growth in infants and for nitrogen equilibrium in human adults. Adequate level in diet may compensate the deficiencies of Niacin and thus mitigate pellagra.

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Primary Characteristics

It is of Semi Synthetic origin and belongs to Amino Acid.

It belongs to Serotonin precursor pharmacological group on the basis of mechanism of action and also classified in Antipsychotic Agent pharmacological group.

Molecular Weight: 204.2 · pK_a: 2.4, 9.4 · Solubility in Water: 1 in 100 · Solubility in Alcohol: > 1 in 10000 · Non-proprietary name: Tryptophan · pH: 3.

Pharmacokinetics

Distribution: Tryptophan has a volume of distribution is 0.34 - 0.71 kg. plasma protein binding is ~ 82 %.

Elimination: plasma half-life is 1.8 - 2.2 hr, renal excretion is 10 - 20 %.

Indications

Tryptophan is primarily indicated in conditions like Depression, Insomnia, Mania, Nausea and vomiting (acute attacks), Obesity, Obsessive-compulsive disorders, Pain, Psychosis.

Tryptophan is also indicated for secondary conditions like Myoclonic seizures.

Contraindications

Tryptophan is contraindicated in conditions like Diabetes mellitus, Cancer, Achlorhydic states, Scleroderma.

Dosage

Tryptophan's dosage details are as follows:

Dose	Single Dose	Frequency	Route
Adult Dosage
3.5 g	3.5 g	Every 8h	PO
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown3 interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Tryptophan produces potentially life-threatening effects which include Eosinophilia , Myalgia . Careful monitoring is needed with proper medical management.

Tryptophan is known to cause more or less tolerable side effects which are usually transient. These include Anorexia , Dizziness, Drowsiness, Headache.

Warnings / Precautions

Patients should observe caution while driving or performing other tasks requiring alertness, because it may produce drowsiness. It is recommended that patient receiving tryptophan should be closely monitored, with particular care being paid to eosinophil count, hematological changes and muscles symptomatology.

Available Brands

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Multi-Ingredient Combinations

Inf

0.68 g/1000ml 0.8 g/L 1 g/1000ml 1.8 g/L 1.9 g/L

Inf

Powder

Soln

Tabs

Storage Conditions

Tryptophan should be stored Tab.

Drug Classification

1.24.2.1 — Drugs used in depression

Manufacturers

Manufacturers of Tryptophan in Pakistan:

B.Braun Mac & Rans Medipak Otsuka Usmanco