Triprolidine (HCl)
Triprolidine (HCl) is antihistamine. Triprolidine (HCl) is effective in the symptomatic treatment of seasonal and perennial allergic rhinitis, allergic conjunctivitis and uncomplicated skin manifestation of urticaria etc.
Primary Characteristics
Triprolidine (HCl) is also known as Triprolidine.
It is of Synthetic origin and belongs to Pyridine.
It belongs to H1-antagonist pharmacological group on the basis of mechanism of action.
Molecular Weight: 332.9 · pKa: 3.6, 9.3 · Solubility in Water: 1 in 2.1 · Solubility in Alcohol: 1 in 1.5 · Non-proprietary name: Triprolidine (HCl).
Pharmacokinetics
Absorption: Triprolidine (HCl) has an oral bioavailability is 83% (±7%).
Distribution: Triprolidine (HCl) has a volume of distribution is 8.7±7.8 l/kg. plasma protein binding is 90%.
Elimination: plasma half-life is 1.5-4.5 hr, renal excretion is 1%.
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Indications
Triprolidine (HCl) is primarily indicated in conditions like Allergic conjunctivitis, Allergic rhinitis, Angioedema, Angiooedema, Common cold, Fever, Urticaria.
Contraindications
Triprolidine (HCl) is contraindicated in conditions like Alcohol dependence, Prostatic hypertrophy, Narrow-angle glaucoma, Hypersensitivity.
Dosage
Triprolidine (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 37.5 mg | 37.5 mg | Every 8h | PO | Frequency may be increased upto 4 times/day if needed. |
| Paediatric Dosage (20kg) | ||||
| 0.2 mg/kg | 0.2 mg/kg | Every 8h | Oral | - |
| Neonatal Dosage (3kg) | ||||
| 0.125 mg/kg | 0.125 mg/kg | Every 8h | Oral | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
The signs and symptoms that are produced after acute overdosage of Triprolidine (HCl) are Respiratory depression, Weakness , Dizziness, Convulsions , Incoordination .
Triprolidine (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Anorexia , Blurred vision, Confusion, Drowsiness, Dysuria, Epigastric discomfort, GI disturbance, Headache, Lassitude , Palpitation, Photosensitivity, Postural hypotension, Skin eruptions, SomnolenceX, Tinnitus, Urinary frequency.
Warnings / Precautions
Available Brands
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Single Ingredient
Multi-Ingredient Combinations
Storage Conditions
Drug Classification
- 1.3 — Anti-allergics (Antihistamines) and drugs used in anaphylaxis
- 2.25.2.1 — Cold preparations