Tubocurarine (Cl)
Tubocurarine is an alkaloid isolated from the bark and stems of Chondodendron tomentosum. The drug tubocurarine was introduced into clinical practice in the early 1940s. Tubocurarine is a skeletal muscle relaxant and structural analogue of acetylcholine. Tubocurarine (Cl) is a non-depolarizing competitive neuromuscular blocking agent. It blocks passage of impulses at the neuromuscular junction. Tubocurarine (Cl) is administered intravenously. The neuromuscular blocking agents have significantly increased the safety of anesthesia ,since less anesthetic is required to produce muscle relaxation.
Primary Characteristics
It belongs to Tubocuranium.
It belongs to Cholinergic nicotinic antagonist pharmacological group on the basis of mechanism of action and also classified in Muscle Relaxants pharmacological group.
Molecular Weight: 681.7 · pKa: 8.0 · Solubility in Water: 1 in 20 · Solubility in Alcohol: 1 in 30 · Non-proprietary name: Tubocurarine (Cl).
Pharmacokinetics
Distribution: Tubocurarine (Cl) has a volume of distribution is 0.3 - 0.6 l/kg. plasma protein binding is 40 - 50 %.
Elimination: plasma half-life is 2 - 4 hr.
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Indications
Tubocurarine (Cl) is primarily indicated in conditions like Myasthenia gravis diagnosis, Surgical muscle relaxant.
Tubocurarine (Cl) is also indicated for secondary conditions like Surgical anaesthesia.
Contraindications
Tubocurarine (Cl) is contraindicated in conditions like Hypovolaemia, Myasthenia gravis, Renal failure, Malignant hyperthermia.
Dosage
Tubocurarine (Cl) 's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0.2 mg/kg | 0.2 mg/kg | — | Slow IV | As Required |
| Paediatric Dosage (20kg) | ||||
| 0.4 mg/kg | 0.4 mg/kg | — | Intra Venous | As Required |
| Neonatal Dosage (3kg) | ||||
| 0.4 mg/kg | 0.4 mg/kg | — | Intra Venous | As Required |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Tubocurarine (Cl) in overdosage may give rise to further complications which include Anaphylactoid reactions .
Tubocurarine (Cl) produces potentially life-threatening effects which include Apnea, Cardiovascular collapse, Ganglionic blockage, Postoperative respiratory failure. Careful monitoring is needed with proper medical management.
Tubocurarine (Cl) is known to cause more or less tolerable side effects which are usually transient. These include Bronchospasm, Erythema, Hypotension , Itching, Urticaria.
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.20 — Muscle relaxants and cholinesterase inhibitors