Trimipramine (Maleate) - Drug Monograph

Primary Characteristics

It is of Synthetic origin and belongs to Tricyclic Ammonium.

It belongs to Amine uptake inhibitor pharmacological group on the basis of mechanism of action and also classified in Antidepressant pharmacological group. It is also classified under Psychotherapeutic Drugs .

Molecular Weight: 410.5 · pK_a: 7.72 · Solubility in Water: 1 in 100 - 1000 · Solubility in Alcohol: 1 in 1 - 10 · Non-proprietary name: Trimipramine (Maleate).

Molecular structure of Trimipramine (Maleate)

Pharmacokinetics

Absorption: Trimipramine (Maleate) has an oral bioavailability is 80%, pre-systemic (first-pass) metabolism accounts for 83% (±7%).

Distribution: Trimipramine (Maleate) has a volume of distribution is 31 l/kg. plasma protein binding is 95 %.

Elimination: it is metabolised via Hepatic, plasma half-life is 7 - 9 hr.

Indications

Trimipramine (Maleate) is primarily indicated in conditions like Anxiety, Depression, Insomnia, Peptic ulcer.

Trimipramine (Maleate) is also indicated for secondary conditions like Digestive disorder.

Contraindications

Trimipramine (Maleate) is contraindicated in conditions like Cardiac arrhythmia, Mania, Myocardial infarction, Liver diseases, Narrow-angle glaucoma.

Dosage

Trimipramine (Maleate)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.893 mg/kg	0.893 mg/kg	Every 24h	PO	-
3.393 mg/kg	3.393 mg/kg	Every 24h	PO	-
Paediatric Dosage (20kg)
0 – 0	—	—		Not recommended in this age group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown11 interactions

2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Trimipramine (Maleate) in overdosage may give rise to further complications which include Agitation .

Trimipramine (Maleate) produces potentially life-threatening effects which include Agranulocytosis, Thrombocytopenia , Jaundice . Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Trimipramine (Maleate) are Drowsiness, Dry mouth, Dilated pupils, Sinus tachycardia.

Trimipramine (Maleate) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Constipation , Dry mouth, Headache, Increased intracranial pressure, Light headedness, Nausea, Postural hypotension, Rashes , Sedation , Tremors.

Warnings / Precautions

Trimepramine should be used with caution in patients with glaucoma, prostate problems, decreased urine output, thyroid disease, breathing problems, seizure problems, alcohol use, heart disease, mental or emotional problems, liver or kidney disease and of any drug allergy. It should be used caution while driving or engaging in tasks requiring alertness such as operating machinery. Limit alcohol consumption as it may increase the drowsiness and dizziness effects of this drug. Limit exposure to hot weather as it may lead to heat stroke. This drug should be used during pregnancy or lactation only if clearly needed.

Available Brands

None recorded.

Storage Conditions

Trimipramine (Maleate) should be stored Caps.

Drug Classification

1.24.2.1 — Drugs used in depression