Trimetaphan (Camsylate)
Trimethaphan is a sulfonium competitive nicotinic ganglionic blocking agent with direct vasodilator action. It has a very short duration of action. Trimetaphan (Camsylate) is used as an antihypertensive to produce controlled hypotension during surgery and for the emergency treatment of hypertensive crisis and pulmonary edema due to hypertension. Historically drugs that block stimulation of post-ganglionic autonomic neurons by acetylcholine were among the first agents used in the treatment of hypertension. Most such drugs are no longer available clinically because of intolerable toxicities related to their primary action. Until recently, trimethaphan was still used to treat hypertension. However, in 1996 it was withdrawn from the market. Trimetaphan (Camsylate) is administered by intravenous infusion.
Primary Characteristics
It is of Synthetic origin and belongs to Dibenzyloxoimidazol.
It belongs to Cholinergic nicotinic antagonist pharmacological group on the basis of mechanism of action and also classified in Antihypertensive Agents pharmacological group.
Molecular Weight: 596.8 · Solubility in Water: 1 in 5 · Solubility in Alcohol: 1 in 2 · Non-proprietary name: Trimetaphan (camsylate).
Pharmacokinetics
None recorded.
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Indications
Trimetaphan (Camsylate) is primarily indicated in conditions like Hypertension, Hypertensive emergencies, Induce hypotension, Myocardial infarction, Prophylaxis of NSAID-induced duodenal ulcer.
Trimetaphan (Camsylate) is also indicated for secondary conditions like Surgery.
Contraindications
Trimetaphan (Camsylate) is contraindicated in conditions like Addison's disease, Pyloric disease, Arteriosclerosis.
Dosage
Trimetaphan (Camsylate)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0.046 mg/kg.min | 0.046 mg/kg.min | — | IV Inf | As Required |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Trimetaphan (Camsylate) in overdosage may give rise to further complications which include Asthma .
Trimetaphan (Camsylate) produces potentially life-threatening effects which include Respiratory arrest. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Trimetaphan (Camsylate) are Tachycardia .
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.12.3.8 — Ganglion blocking drugs