Trimeprazine (Tartrate)

Also known as: Alimemazine Tartrate

Drug #736

Trimeprazine (Tartrate) is a phenothiazine similar to chlorpromazine. Trimeprazine (Tartrate) is used as an antiemetic, sedative and antipruritic agent. Trimeprazine (Tartrate) is used in urticaria and for prolong relief of pruritic symptoms in a variety of allergic and non-allergic conditions.

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Primary Characteristics

Trimeprazine (Tartrate) is also known as Alimemazine Tartrate.

It is of Synthetic origin and belongs to Phenothiazine.

It belongs to H1-antagonist pharmacological group on the basis of mechanism of action.

Molecular Weight: 747 · pK_a: 9.2 · Solubility in Water: 1 in 4 · Solubility in Alcohol: 1 in 30 · Non-proprietary name: Trimeprazine (Tartrate).

Molecular structure of Trimeprazine (Tartrate)

Pharmacokinetics

Absorption: Trimeprazine (Tartrate) has an oral bioavailability is 85% (±5%).

Distribution: Trimeprazine (Tartrate) has a plasma protein binding is > 90 %.

Elimination: plasma half-life is 3.6 - 7 hr, renal excretion is 70 %.

Indications

Trimeprazine (Tartrate) is primarily indicated in conditions like Allergy, Insomnia, Premedication in anaesthesia, Pruritus, Urticaria, Urticaria and pruritus.

Contraindications

Trimeprazine (Tartrate) is contraindicated in conditions like Epilepsy, Glucoma, Myasthenia gravis, Parkinsonism, Prostatic hypertrophy.

Dosage

Trimeprazine (Tartrate)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.19 mg/kg	0.19 mg/kg	Every 8h	PO	-
Paediatric Dosage (20kg)
0.25 mg/kg	0.25 mg/kg	Every 8h	Oral	-
Neonatal Dosage (3kg)
0.25 mg/kg	0.25 mg/kg	Every 8h	Oral

Drug Interactions

Unknown3 interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Trimeprazine (Tartrate) in overdosage may give rise to further complications which include Hypoglycemia.

Trimeprazine (Tartrate) produces potentially life-threatening effects which include Respiratory depression, Hypotension, Malignant hyperpyrexia. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Trimeprazine (Tartrate) are Tachycardia , Respiratory failure, Hypoventilation , Extrapyramidal effects , Anticholinergic effects.

Trimeprazine (Tartrate) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal discomfort, Depression, Drowsiness, Dry mouth, Galactorrhea, Headache, Nasal congestion , Photosensitive dermatitis, Vivid dreams.

Warnings / Precautions

Trimeprazine should be used with caution in bone marrow depression. Patients should observe caution while driving or performing other task requiring alertness because it may cause drowsiness. It should be used with caution in patients with urinary retention, history of bronchial asthma, hyperthyroidism, cardiovascular or liver disease. It should be used with caution in person with acute or chronic respiratory impairment, especially in children. Do not administer S/C because irritation or lesion may occur.

Available Brands

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Multi-Ingredient Combinations

Tabs

160 mg

Storage Conditions

Trimeprazine (Tartrate) should be stored Tab, Cap, Syrup.

Drug Classification

1.3 — Anti-allergics (Antihistamines) and drugs used in anaphylaxis
2.13.3.3 — Antipruritics

Manufacturers

Manufacturers of Trimeprazine (Tartrate) in Pakistan:

Dosaco