Trifluoperazine (HCl)
Trifluoperazine (HCl) is a phenothiazine similar to chlorpromazine. Trifluoperazine (HCl) is used to treat symptoms of certain types of mental or emotional conditions such as anxiety, tension and agitation. Trifluoperazine (HCl) is also used to treat nausea and vomiting.
Primary Characteristics
It is of Synthetic origin and belongs to Phenothiazine.
It belongs to D2 antagonist pharmacological group on the basis of mechanism of action. It is also classified under Psychotherapeutic Drugs .
Molecular Weight: 480.4 · pKa: 8.1 · Solubility in Water: 1 in 2 · Solubility in Alcohol: 1 in 11 · Non-proprietary name: Trifluoperazine (HCl).
Pharmacokinetics
Absorption: Trifluoperazine (HCl) has an oral bioavailability is 100%, pre-systemic (first-pass) metabolism accounts for 83% (±7%).
Distribution: Trifluoperazine (HCl) has a volume of distribution is 160 l/kg. plasma protein binding is > 99 %.
Elimination: plasma half-life is 7 - 18 hr, renal excretion is 7 %.
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Indications
Trifluoperazine (HCl) is primarily indicated in conditions like Agitation, Anxiety, Diagnostic procedures, Enhance permeation of SC or IM inj, Muscle spasm of varied aeitology, Nausea and vomiting, Psychosis, Schizophrenia, Severe nausea and vomiting.
Contraindications
Trifluoperazine (HCl) is contraindicated in conditions like Blood dyscrasias, Bone marrow depression, Coma, Liver diseases.
Dosage
Trifluoperazine (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 1.5 mg | 1.5 mg | Every 12h | PO | Frequency may be increased upto 3 times/day if needed. |
| Paediatric Dosage (20kg) | ||||
| 0.035 mg/kg | 0.035 mg/kg | Every 6h | Oral | - |
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Trifluoperazine (HCl) in overdosage may give rise to further complications which include Tardive dyskinesia .
The signs and symptoms that are produced after acute overdosage of Trifluoperazine (HCl) are Hypotension, Akathisia , Torticollis , Dystonic syndrome .
Trifluoperazine (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Anorexia , Blurred vision, Dizziness, Drowsiness, Dry mouth, Dyskinesia , Dystonia , Insomnia, Lassitude , Motor restlessnes, Postural hypotension.
Warnings / Precautions
Interference in Pathology
Trifluoperazine (HCl) may interfere in the diagnosis of Determination of Urinaary Ketones and Urobilinogen .
Available Brands
Storage Conditions
Drug Classification
- 1.24.1 — Drugs used in psychotic disorders