DrugInfoSys

Tretinoin

Also known as: Retinoic Acid

Drug #731

Tretinoin is a vitamin A derivative. When applied topically, effective for the treatment of acne and to reudce photo-damage due to excessive exposure to sun light. Tretinoin is also used in conjuction with chemotherapy in the treatment of certain leukemias.

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Primary Characteristics

Tretinoin is also known as Retinoic Acid.

It is of Synthetic origin and belongs to Tetraenoic Acid.

It is classified in Retinoic Acid Derivative pharmacological group. It is also classified under Dermatological Products .

Molecular Weight: 300.4 · Solubility in Water: Insoluble · Solubility in Alcohol: slightly · Non-proprietary name: Tretinoin.

Molecular structure of Tretinoin

Pharmacokinetics

Distribution: Tretinoin has a plasma protein binding is > 95 %.

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Indications

Tretinoin is primarily indicated in conditions like Acne vulgaris, Promyelocytic leukemia.

Tretinoin is also indicated for secondary conditions like Naevus comedonicus, Pseudofolliculitis, Senile comedones, Trichostasis spinulosa.

Contraindications

None recorded.

Dosage

Tretinoin's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
0.05 %0.05 %Every 24hTopicalAs Required
Paediatric Dosage (20kg)
0 – 0——Not recommended in this age group
Neonatal Dosage (3kg)
0 – 0——Not recommended in this age group

Drug Interactions

Unknown7 interactions
1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Tretinoin is known to cause more or less tolerable side effects which are usually transient. These include Erythema, Irritation, Warmth feeling.

Warnings / Precautions

Tretinoin should be used with caution in patients with any illness or allergy, especially to any drug including parabens preservatives. It is recommended that persons using this medication not donate blood for at least three years after stopping therapy. It should not be used during pregnancy or lactation. Photosensitization may occur, caution patients to take protective measures, i.e.wearing protective clotting or sunscreen, before exposure to UV or sunlight. Use other acne preparation (if it is use topically) with caution while using tretinoin.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Cream
0.05 %w/w
Lotion
0.05 %w/v

Multi-Ingredient Combinations

Cream
0.05 %w/w
Gel
0.025 %w/w

Storage Conditions

Tretinoin should be stored Caps. Cream. Gel, Liq.

Drug Classification

  1. 1.13.5.1 — Antiacne preparations

Manufacturers