Treosulfan
Also known as: Dihydroxybusulphan
Treosulfan is antineoplastic (anticancer) agent, related to busulphan. it used in the treatment of ovarian cancer. Treosulfan is metabolized by liver and converted into epoxide form, which is the active form of the drug. It acts by demagining the DNA and thus interfering with cell replication. Treosulfan is used in combination with different anticancer drugs to achieve best therapeutic results and to reduce toxicity or side effects.
Primary Characteristics
Treosulfan is also known as Dihydroxybusulphan.
It is of Synthetic origin and belongs to Methane Sulphonate.
It belongs to Alkylating Agents pharmacological group on the basis of mechanism of action and also classified in Antineoplastic Agent, Alkylating Agent pharmacological group.
Molecular Weight: 278.3 · pKa: not relevant · Solubility in Water: 1 in 14 · Solubility in Alcohol: 1 in 200 · Non-proprietary name: Treosulfan.
Pharmacokinetics
Absorption: Treosulfan has an oral bioavailability is 60.5% (±9.5%).
Distribution: Treosulfan has a volume of distribution is 44-88 litre.
Elimination: plasma half-life is 1.4 - 1.9 hr, renal excretion is 11 - 21 %.
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Indications
Treosulfan is primarily indicated in conditions like Ovarian cancer.
Contraindications
None recorded.
Dosage
Treosulfan's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 3.571 mg/kg | 3.571 mg/kg | Every 6h | PO | - |
| 142.857 mg/kg | 142.857 mg/kg | — | Slow IV | Every 1-3 Week |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
None recorded.
Side Effects
Treosulfan in overdosage may give rise to further complications which include Myelosuppressive effect .
Treosulfan produces potentially life-threatening effects which include Bone marrow suppression, Myelogenous leukemia. Careful monitoring is needed with proper medical management.
Treosulfan is known to cause more or less tolerable side effects which are usually transient. These include Nausea and vomiting, Skin pigmentation, Stomatitis, Thrombocytopenia.
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.8.2 — Cytotoxic (anti-neoplastic) drugs