Trazodone (HCl)
Trazodone (HCl) is oral antidepressant, unrelated to other known antidepressants. It possesses some similarities of action to other antidepressant drugs, however, and also has some action as an anxiolytic. Antidepressant activity is believed to be produced by blocking the reuptake of serotonin at the presynaptic neuronal membrane. Long-term therapy also can affect postsynaptic neuronal receptor binding sites. Trazodone is used in the treatment of major depression, generalized anxiety disorder, and insomnia. Trazodone was approved by the FDA in 1981.
Primary Characteristics
It belongs to Phenylpiperazine.
It belongs to Amine uptake inhibitor pharmacological group on the basis of mechanism of action and also classified in Antidepressant pharmacological group. It is also classified under Psychotherapeutic Drugs .
Molecular Weight: 408.3 · pKa: 6.7 · Solubility in Water: freely · Solubility in Alcohol: low · Non-proprietary name: Trazodone (HCl).
Pharmacokinetics
Absorption: Trazodone (HCl) has an oral bioavailability is 100%.
Distribution: Trazodone (HCl) has a volume of distribution is 1.0(0.9-1.1)l/kg. plasma protein binding is 89 - 95 %.
Elimination: plasma half-life is 1.0 - 4.4 hr, renal excretion is > 75 %.
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Indications
Trazodone (HCl) is primarily indicated in conditions like Anxiety, Depression.
Contraindications
None recorded.
Dosage
Trazodone (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 150 mg | 150 mg | Every 24h | PO | Increase dose to 300 mg after 1 week. |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Safety not Established | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Safety not Established | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Trazodone (HCl) in overdosage may give rise to further complications which include Cardiac arrhythmias, Palpitation , Bradycardia , Impotence , Syncope .
The signs and symptoms that are produced after acute overdosage of Trazodone (HCl) are ECG alterations, Seizures, Respiratory arrest, Priapism .
Trazodone (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Changes in libido , Dizziness, Drowsiness, Headache, Incoordination , Increased intracranial pressure, Loss of memory, Nasal congestion .
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.24.2.1 — Drugs used in depression