Tranylcypromine (Sulphate)
Also known as: Transamine Sulphate
Tranylcypromine (Sulphate) is antidepressant agent, belongs to monoamino oxidase inhibitors. Tranylcypromine (Sulphate) is effective for the symptomatic relief of severe reactive or endogenous depression in patient who have not responded to other anti-depressant therapy.
Primary Characteristics
Tranylcypromine (Sulphate) is also known as Transamine Sulphate.
It is of Synthetic origin and belongs to Phenylcyclopropylamine.
It is classified in Antidepressant pharmacological group. It is also classified under Psychotherapeutic Drugs .
Molecular Weight: 364.5 · pKa: 8.2 · Solubility in Water: 1 in 25 · Solubility in Alcohol: Insoluble · Non-proprietary name: Tranylcypromine (Sulphate).
Pharmacokinetics
Absorption: Tranylcypromine (Sulphate) has an oral bioavailability is 83% (±7%).
Elimination: it is metabolised via Hepatic, plasma half-life is 1.5 - 2.7 hr, renal excretion is 5 %.
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Indications
Tranylcypromine (Sulphate) is primarily indicated in conditions like Depression, Neurosis, Psychosis.
Tranylcypromine (Sulphate) is also indicated for secondary conditions like Anxiety, Phobias.
Contraindications
Tranylcypromine (Sulphate) is contraindicated in conditions like Alcohol dependence, Hyperthyroidism, Phaeochromocytoma, Blood dyscrasias, Liver diseases, Cardiovascular disease, Cerebrovascular disease.
Dosage
Tranylcypromine (Sulphate)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0.143 mg/kg | 0.143 mg/kg | Every 12h | PO | Initially for 1 Week |
| 0.357 mg/kg | 0.357 mg/kg | Every 12h | PO | Maintenance, As Required |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Not indicated in this age group | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not indicated in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Tranylcypromine (Sulphate) in overdosage may give rise to further complications which include Liver dysfunction .
Tranylcypromine (Sulphate) produces potentially life-threatening effects which include Severe sympathomimetic crisis. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Tranylcypromine (Sulphate) are Tachycardia , Fever, Headache, Convulsions , Agitation, Coma and death, Tachypnea, Hypertension, Mental confusion, Neuromuscular weakness, Chest pain.
Tranylcypromine (Sulphate) is known to cause more or less tolerable side effects which are usually transient. These include Anticholinergic side effects, Drowsiness, Headache, Nausea, Palpitation, Peripheral neuropathy, Restlessness, Weakness, Weight gain.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.24.2.1 — Drugs used in depression