Tranexamic Acid
Tranexamic Acid is antifibrinolytic agent. Tranexamic Acid is analogue of aminocaproic acid. Chemically Tranexamic Acid is identified as trans-4-(aminomethyl) cyclohexanecarboxylic acid. Tranexamic Acid is effective to reversed the effects of streptokinase or other fibrinolytic activity. It may be used for conditions in which bleeding control is required such as after surgery or injury, recurrent nosebleeds or abnormal vaginal bleeding.
Primary Characteristics
It is of Synthetic origin and belongs to Amino Acid.
It belongs to Plasminogen inhibitor pharmacological group on the basis of mechanism of action and also classified in Tranexamic Acid and Antihemophillic Agent pharmacological group.
Molecular Weight: 157 · pKa: 4.3, 10.6 · Solubility in Water: 1 in 6 · Solubility in Alcohol: 1 in 1000 - 10000 · Non-proprietary name: Tranexamic Acid.
Pharmacokinetics
Absorption: Tranexamic Acid has an oral bioavailability is 50%.
Distribution: Tranexamic Acid has a volume of distribution is 1 l/kg. plasma protein binding is negligible.
Elimination: plasma half-life is 1.4 hr, renal excretion is extensive.
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Indications
Tranexamic Acid is primarily indicated in conditions like Acute spasm and spasm in diagnostic procedures, Angioneurotic edema, Haemophilia, Prevention of bleeding, Subarachnoid haemorrhage.
Tranexamic Acid is also indicated for secondary conditions like Epistaxis, GI hemorrhage, Menorrhagia.
Contraindications
Tranexamic Acid is contraindicated in conditions like Thrombosis, Renal diseases, Color blindness, Hematuria.
Dosage
Tranexamic Acid's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 500 mg | 500 mg | Every 8h | PO | |
| 0.75 g | 0.75 g | Every 8h | Slow IV | Local fibrinolysis |
| Paediatric Dosage (20kg) | ||||
| 25 mg/kg | 25 mg/kg | Every 8h | Oral | - |
| Neonatal Dosage (3kg) | ||||
| 25 mg/kg | 25 mg/kg | Every 8h | Oral | - |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Tranexamic Acid in overdosage may give rise to further complications which include Acute renal failure , Myopathy .
Tranexamic Acid produces potentially life-threatening effects which include Intracranial thrombosis. Careful monitoring is needed with proper medical management.
Tranexamic Acid is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Nausea, Purpura, Rashes .
Warnings / Precautions
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.10.3 — Antihemorrhagics/Antihemophilics
Manufacturers
Manufacturers of Tranexamic Acid in Pakistan: