Tolmetin (Na)

Drug #726

Tolmetin (Na) is a pyrroleacetic acid derivative. It reduces inflammation, fever and relieves pain. Tolmetin (Na) is a non steroidal anti-infalmmatory agent more potent than Aspirin but less potent than Indomethacin.

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Primary Characteristics

It is of Synthetic origin and belongs to Pyrrole.

It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action. It is also classified under Analgesics and Anti-inflammatory Agents .

Molecular Weight: 315.3 · pK_a: 3.5 · Solubility in Water: soluble · Solubility in Alcohol: Insoluble · Non-proprietary name: Tolmetin (Na).

Pharmacokinetics

Absorption: Tolmetin (Na) has an oral bioavailability is 99%, pre-systemic (first-pass) metabolism accounts for 45.5% (±4.5%).

Distribution: Tolmetin (Na) has a volume of distribution is 0.098 l/kg. plasma protein binding is 99.7 %.

Elimination: it is metabolised via Hepatic, plasma half-life is 5.5 - 8.5 hr, renal excretion is 99 %.

Indications

Tolmetin (Na) is primarily indicated in conditions like Ankylosing spondylitis, Osteoarthritis, Pain, Pre-articular disorder, Rheumatoid arthritis.

Contraindications

Tolmetin (Na) is contraindicated in conditions like Peptic ulcer.

Dosage

Tolmetin (Na)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
5.71 mg/kg	5.71 mg/kg	Every 8h	PO	-
Paediatric Dosage (20kg)
7.5 mg/kg	7.5 mg/kg	Every 8h	Oral	Not Recommended in Childrens under 2 Yrs
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Major1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Tolmetin (Na) produces potentially life-threatening effects which include Agranulocytosis, Renal failure, Hepatic failure. Careful monitoring is needed with proper medical management.

Tolmetin (Na) is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Dizziness, Edema, Flatulence, GI disturbance, Headache, Hearing loss, Hypertension , Nausea, Rashes , Tinnitus, Vomiting , Weight gain, Weight loss.

Warnings / Precautions

Tolmetin should be used with caution in patients with intrinsic coagulation defects and those on anticoagulant therapy. It should be used with caution in patients with compromised cardiac function, hypertension other condition predisposing to fluid retention. It should be used with extra care in the presence of existing controlled infection. Perform periodic auditory (hearing) function test during chronic therapy. Discontinue drug if skin reaction occurs.

Interference in Pathology

Tolmetin (Na) may interfere in the diagnosis of Test for Proteinuria by acid Precipitation Method .

Available Brands

None recorded.

Storage Conditions

Tolmetin (Na) should be stored Tab, Caps.

Drug Classification

1.2.1.3 — Non steroidal anti-inflammatory drugs (NSAIDs)