Tocopherol (Vitamin E)

Drug #723

Tocopherol (Vitamin E) is a most active and widely distributed form of vitamin E found in nature. Tocopherol (Vitamin E) is a fat soluble vitamin. Tocopherol (Vitamin E) is involved in the prevention of oxidation of fatty acid. It reacts with free radicals, which are the cause of oxidative demage to cell membranes, without the formation of another free radical in the process. Vitamin E is used in the prevention and treatment of vitamin E deficiency, which may be developed due to inadequate dietry intake or some congenital disorders such as cystic fibrosis. Vitamin E is also included in some dermatological products due to its antiaging properties. Tocopherol (Vitamin E) is widely distributed in foods. The richest sources are vegetable fats and oils especially wheat germ oil, sunflower oil and cottonseed oil, dairy products, meat, eggs, cereals, nuts and leafy green and yellow vegetables. Tocopherol (Vitamin E) is also used as a antoxidant in pharmaceutical manufacturing.

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Primary Characteristics

It is of Synthetic origin and belongs to Tocopheryl Acetate.

It is classified in Vitamin, Fat Soluble pharmacological group.

Molecular Weight: 472.8 · Solubility in Water: < 1 in 10000 · Solubility in Alcohol: > 1 in 2 · Non-proprietary name: Tocopherole (Vitamin E).

Molecular structure of Tocopherol (Vitamin E)

Pharmacokinetics

Elimination: it is metabolised via Hepatic, renal excretion is low.

Indications

Tocopherol (Vitamin E) is primarily indicated in conditions like Cardiovascular disease, Dementia, Haemolytic anaemia, Hepatotoxin poisoning, Metal poisoning, Vitamin deficiency.

Tocopherol (Vitamin E) is also indicated for secondary conditions like Malignant neoplasms, Muscular spasm, Parkinsonism, Prophylaxis and treatment of angina, Retinopathy, Surgery.

Contraindications

None recorded.

Dosage

Tocopherol (Vitamin E)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
1.5 mg /kg	1.5 mg /kg	Every 24h	IM
50 – 200 mg /kg	—	Every 24h	PO
Paediatric Dosage (20kg)
3 mg/kg	3 mg/kg	Every 24h	Oral	-
Neonatal Dosage (3kg)
3 mg/kg	3 mg/kg	Every 24h	Oral

Drug Interactions

Unknown3 interactions

2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Tocopherol (Vitamin E) in overdosage may give rise to further complications which include Thrombosis , bleeding in vitamin K deficient patients., necrotizing enterocolitis in premature infants.

Tocopherol (Vitamin E) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Blurred vision, Diarrhea, Dizziness, Fatigue, Flatulence, Hypertension , Myopathy, Nausea, Thrombophlebitis , Weakness.

Warnings / Precautions

Tocopherol may be used with caution during pregnancy or lactation. It should be used with caution in patients with any skin infection, skin disorder, are sensitive to any topical lotions or creams or if have any allergy. Sholud not be given to premature infants.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Caps

Caps

Cream

Dragees

Drops

Soft Caps

1000 IU 200 mg 400 mg 600 mg

Tabs

1.5 mg 100 mg

Multi-Ingredient Combinations

Caps

0.2 mg 1 mg 10 mg 100 mg 3 mg 3.3 mg 30 IU 30 mg 40 mg 5 IU 6.7 mg 60 mg 70 mg 75 mg

Caps

Dragees

Dragees

Eye Oint

Inf

Inj

Liquid

0.5 IU/5ml 0.5 mg/5ml

Mouth Wash

0.04 g

Soft Caps

0.2 mg 2 mg

Syrup

1.5 mg/5ml 10 mg/5ml 2.5 mg/5ml 3 mg/15ml 3 mg/5ml

Tabs

1 IU 1 mg 1.5 mg 10 mg 100 IU 100 mg 12.1 IU 125 mg 15 IU 15 mg 2 IU 200 IU 3 mg 30 IU 30 mg 45 IU 5 IU 5 mg 50 IU 60 IU 70 mg

Tabs efr

5 mg

Storage Conditions

Tocopherol (Vitamin E) should be stored Cap, Tab, Oral soln.

Drug Classification

1.13.5.1 — Antiacne preparations
2.27 — Vitamins, minerals, tonics, and other susbstances

Manufacturers

Manufacturers of Tocopherol (Vitamin E) in Pakistan: