Tocainide (HCl)

Drug #722

Tocainide (HCl) is investigational anti-arrhythmic agent. Chemically Tocainide (HCl) is a 2-amino-N-(2, 6-dimethylphenyl) propanamide. Tocainide (HCl) is a homologue of the desethyl metabolite of lidocaine. Tocainide (HCl) is resistant to first pass metabolism. its antiarrhythmic action is similar to that of lidocaine.

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Primary Characteristics

It is of Synthetic origin and belongs to Primary Amine.

It belongs to Na-Channel Antiarrhythmic antagonist pharmacological group on the basis of mechanism of action and also classified in Anti arrhythmic agents pharmacological group.

Molecular Weight: 228.7 · pK_a: 7.7 · Solubility in Water: freely · Solubility in Alcohol: freely · Non-proprietary name: Tocainide (HCl).

Pharmacokinetics

Absorption: Tocainide (HCl) has an oral bioavailability is 100%.

Distribution: Tocainide (HCl) has a volume of distribution is 1.46 - 3.2 l/kg. plasma protein binding is 4 - 22 %.

Elimination: it is metabolised via Hepatic, plasma half-life is 8.9 - 40.6 hr, renal excretion is 40 - 50 %.

Indications

Tocainide (HCl) is primarily indicated in conditions like Myocardial infarction, Ventricular arrhythmias.

Contraindications

Tocainide (HCl) is contraindicated in conditions like Av block of ii &iii degree.

Dosage

Tocainide (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
10 mg/kg	10 mg/kg	Every 8h	PO	Maintenance, As Required
8.93 mg/kg	8.93 mg/kg	Every 24h	Slow IV	Initially for Once
Paediatric Dosage (20kg)
0 – 0	—	—		Safety not established
Neonatal Dosage (3kg)
0 – 0	—	—		Safety not established

Drug Interactions

Unknown9 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Tocainide (HCl) in overdosage may give rise to further complications which include Fibrosing alveolitis , Interstitial pneumonitis , Lupus erythematosus , Pneumonitis , Pulmonary fibrosis , Pulmonary edema.

Tocainide (HCl) produces potentially life-threatening effects which include Agranulocytosis, Thrombocytopenia , Blood dyscrasias, Aplastic Anemia , Leucopenia , Aggravation of ventricular arrhythmias . Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Tocainide (HCl) are Respiratory depression, Convulsions , Excitation , Cardiovascular disturbances.

Tocainide (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Convulsions , Diarrhea, Headache, SweatingX, Visual hallucinations.

Warnings / Precautions

Tocainide should be used with caution in patients of liver or kidney diseases because the rate of elimination may be significantly decreased. Correct any potassium deficit because tocainide is ineffective in hypokalemia.

Available Brands

None recorded.

Storage Conditions

Tocainide (HCl) should be stored Tab.

Drug Classification

1.12.2 — Antiarrhythmic drugs