Tienilic Acid
Tienilic Acid is a diuretic. It was formerly used in the treatment of edema and hypertension, but it has been withdrawn from the market due to severe side effects.
Primary Characteristics
It is of Synthetic origin and belongs to Acetic Acid.
It belongs to Renal tubular anion resorption inhibitor pharmacological group on the basis of mechanism of action and also classified in Diuretics pharmacological group.
Molecular Weight: 331.2 · pKa: 2.7 · Solubility in Water: slightly soluble · Solubility in Alcohol: 1 in 14 · Non-proprietary name: Tienilic Acid.
Pharmacokinetics
Absorption: Tienilic Acid has an oral bioavailability is 60.5% (±9.5%).
Distribution: Tienilic Acid has a plasma protein binding is 99.5 %.
Elimination: plasma half-life is 2.3 - 5 hr.
Advertisement
Indications
Tienilic Acid is primarily indicated in conditions like Hypertension, Infertility without hyperprolactinaemia.
Contraindications
Tienilic Acid is contraindicated in conditions like Thrombosis, Liver diseases, Renal calculi.
Dosage
Tienilic Acid's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 5.36 mg/kg | 5.36 mg/kg | Every 24h | PO | For atleast 6-Months |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Tienilic Acid in overdosage may give rise to further complications which include Arthralgia , Dermatitis , Hypokalemia .
Tienilic Acid produces potentially life-threatening effects which include Renal failure, Hepatotoxicity . Careful monitoring is needed with proper medical management.
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.99 — Unassigned