Ticarcillin (di Na)

Drug #717

Ticarcillin is a carboxypenicillin antibiotic. Penicillin is derived directly or indirectly from strains of fungi of the genus Penicillium and other soil inhabiting fungi grown on special culture media. Penicillins are active against most bacteria especially gram positive pathogen (streptococci, staphylococci, pneumococci), some negative starins (gonococci, meningoccocci), some spirochetes and some fugi. The structure of penicillin consists of a thiazolidine ring connected to a ß lactam ring, which is attached to a side chain. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular intervals of time throughout the day and night as prescribed. Ticarcillin (di Na) is important to take the drug for the full time period as prescribed. Discontinuation of the drug, may result in ineffective treatment.

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Primary Characteristics

It is of Semi Synthetic origin and belongs to Penicillanic Acid.

It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.

Molecular Weight: 428.4 · pK_a: 2.44, 3.64 · Solubility in Water: 1 in 10 · Solubility in Alcohol: 1.5 in 100 · Non-proprietary name: Ticarcillin (di Na).

Molecular structure of Ticarcillin (di Na)

Pharmacokinetics

Absorption: Ticarcillin (di Na) has an oral bioavailability is 0.5% (±0.5%).

Distribution: Ticarcillin (di Na) has a volume of distribution is 0.21 l/kg. plasma protein binding is 45 - 65 %.

Elimination: it is metabolised via Hepatic, plasma half-life is 67 - 76 min.

Indications

Ticarcillin (di Na) is primarily indicated in conditions like Anaerobic infections, Bacterial infections, Infections due to pseudomonas aeruginosa, proteus spp. and bacteroides fragilis, Respiratory tract infections, Septicaemia, UTI.

Contraindications

None recorded.

Dosage

Ticarcillin (di Na)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
83.33 mg/kg	83.33 mg/kg	Every 8h	Slow IV	-
Paediatric Dosage (20kg)
62.5 mg/kg	62.5 mg/kg	Every 6h	Intra Muscular	-
62.5 mg/kg	62.5 mg/kg	Every 6h	Intra Venous	-
Neonatal Dosage (3kg)
62.5 mg/kg	62.5 mg/kg	Every 6h	Intramuscular
62.5 mg/kg	62.5 mg/kg	Every 6h	Intravenous

Drug Interactions

Unknown2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Ticarcillin (di Na) in overdosage may give rise to further complications which include Nephrotoxicity , Neurotoxicity , Neutropenia , Ototoxicity , Platelet dysfunction , Thrombocytopenia .

Ticarcillin (di Na) produces potentially life-threatening effects which include Anaphylactoid reactions . Careful monitoring is needed with proper medical management.

Ticarcillin (di Na) is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Glossitis, Nausea and vomiting, Oral moniliasis, Phlebitis .

Warnings / Precautions

Ticarcillin should be used with caution in patients with any other illness or any allergy especially to penicillin or other antibiotics. It should be used only if clearly needed during pregnancy or lactation.

Available Brands

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Single Ingredient

Inf

3.2 g

Storage Conditions

Ticarcillin (di Na) should be stored IV Inj (reconstituted soln).

Drug Classification

1.6.2.1.1 — Penicillins

Manufacturers

Manufacturers of Ticarcillin (di Na) in Pakistan:

GSK