Tiaprofenic Acid

Drug #716

Tiaprofenic Acid is NSAID ( non steroidal antinflammatory drug), similar to ibuprofen. It reduces inflammation and fever and relieves pain. Tiaprofenic Acid is also used in the treatment of arthritis, headaches and menstrual cramps.

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Primary Characteristics

It is of Synthetic origin and belongs to Propionic Acid.

It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action. It is also classified under Analgesics and Anti-inflammatory Agents .

Molecular Weight: 260.3 · pK_a: 3.0 · Solubility in Water: sparingly · Solubility in Alcohol: 1 in 5 · Non-proprietary name: Tiaprofenic Acid.

Pharmacokinetics

Distribution: Tiaprofenic Acid has a plasma protein binding is 97 - 98 %.

Elimination: plasma half-life is 1.5 - 2 hr, renal excretion is 60 %.

Indications

Tiaprofenic Acid is primarily indicated in conditions like Ankylosing spondylitis, Musculoskeletal disorders, Nausea and vomiting (palliative care), Osteoarthritis, Pain, Rheumatoid arthritis.

Contraindications

Tiaprofenic Acid is contraindicated in conditions like Peptic ulcer, Renal diseases.

Dosage

Tiaprofenic Acid's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
300 mg	300 mg	Every 12h	PO
Paediatric Dosage (20kg)
0 – 0	—	—		Not recommended in this age group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

11 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Tiaprofenic Acid produces potentially life-threatening effects which include Hemorrhage , Agranulocytosis, Renal failure, Hepatic failure. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Tiaprofenic Acid are Epigastric pain, Nausea.

Tiaprofenic Acid is known to cause more or less tolerable side effects which are usually transient. These include Drowsiness, Gastritis, Heart burn, Nausea and vomiting, Paresthesias, Skin rashes, SweatingX.

Warnings / Precautions

Avoid use in patients with prior history of urinary symptoms and discontinue at first sign of genitourinary problems. Severe cases of cystitis (bladder pain, dysuria, urinary frequency, hematuria) due to tiaprofenic acid have been reported. Safety and efficacy have not been established in pediatric patients. Elderly are at a high risk for adverse effects from NSAIDs. As many as 60% of elderly can develop peptic ulceration and/or hemorrhage asymptomatically.

Interference in Pathology

Tiaprofenic Acid may interfere in the diagnosis of Zimmerman Reaction .

Available Brands

None recorded.

Storage Conditions

Tiaprofenic Acid should be stored Tab, Cap.

Drug Classification

1.2.1.3 — Non steroidal anti-inflammatory drugs (NSAIDs)