Thiamine HCl (Vitamin B1)
Also known as: Fursultamine, Aneurine HCl
Thiamine HCl (Vitamin B1) is a heat labile, water soluble bicyclic compound. Thiamine HCl (Vitamin B1) is made up of a substituted pyramidine ring connected by a methylene bridge to the nitrogen of a substituted thiazole ring. Thiamine HCl (Vitamin B1) is involved in carbohydrate metabolism in the body. it's supplements are required to treat or prevent stomach, heart or nerve problems caused by inappropriate amount of thiamine. Thiamine deficiency can occur as a result of malnutrition or in conditions requiring increased need, such as pregnancy or illness. Thiamine HCl (Vitamin B1) is widely distributed in food, found in all plants and synthesized by some microrganisms, perticularly yeast. Cereals, nuts, peas, beans, liver, heart or kidney and fish are rich sources of thiamine.
Primary Characteristics
Thiamine HCl (Vitamin B1) is also known as Fursultamine, Aneurine HCl.
It is of Synthetic origin and belongs to Thiopyrimidine.
It is classified in Vitamin, Water Soluble pharmacological group.
Molecular Weight: 337.3 · pKa: 4.8 · Solubility in Water: 1 in 1 · Solubility in Alcohol: 1 in 100 · Non-proprietary name: Thiamine HCl (Vitamin B1) · pH: 3 · Isotonic value: 4.24.
Pharmacokinetics
Absorption: Thiamine HCl (Vitamin B1) has an oral bioavailability is 73% (±2%).
Distribution: Thiamine HCl (Vitamin B1) has a plasma protein binding is 90-94%.
Elimination: it is metabolised via hepatic, plasma half-life is 24 hr.
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Indications
Thiamine HCl (Vitamin B1) is primarily indicated in conditions like Lung cancer and pancreatic cancer, Mild chronic deficiency, Severe deficiency, Thiamine deficiency prophylaxis, Thiamine deficiency treatment.
Contraindications
None recorded.
Dosage
Thiamine HCl (Vitamin B1)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 200 mg | 200 mg | Every 24h | PO,IM | IV doses should be administered slowly atleast over 20 min to reduce Idiosyncratic reactions |
| Paediatric Dosage (20kg) | ||||
| 1 mg/kg | 1 mg/kg | Every 24h | Intra Muscular | - |
| 1 mg/kg | 1 mg/kg | Every 24h | Oral | - |
| Neonatal Dosage (3kg) | ||||
| 0.625 mg/kg | 0.625 mg/kg | Every 24h | Intramuscular | |
| 0.625 mg/kg | 0.625 mg/kg | Every 24h | Oral | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Thiamine HCl (Vitamin B1) in overdosage may give rise to further complications which include Urticaria , Gi bleeding , Pruritis , Hemorrhage, Pulmonary edema, Cyanosis , Nausea , Angioneurotic edema, Restlessness , Anaphylactic reactions .
Thiamine HCl (Vitamin B1) is known to cause more or less tolerable side effects which are usually transient. These include Anorexia , Ataxia, Dizziness, Faintness , Heaviness, Lethargy, Nausea, SomnolenceX, Soreness , SweatingX.
Warnings / Precautions
Available Brands
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Multi-Ingredient Combinations
Storage Conditions
Drug Classification
- 1.27 — Vitamins, minerals, tonics, and other susbstances
Manufacturers
Manufacturers of Thiamine HCl (Vitamin B1) in Pakistan: