Thiacetazone

Also known as: Amithiozone, Thioacetazone

Drug #709

Thioacetazone is an an anti tuberculous agent and is used to treat tuberculousis (T.B), as an alternative para-aminosalicylic acid.

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Primary Characteristics

Thiacetazone is also known as Amithiozone, Thioacetazone.

It is of Synthetic origin and belongs to Benzaldehyde / Thiosemicarbazone.

It belongs to Antimycobacterial agent pharmacological group on the basis of mechanism of action. It is also classified under Antituberculous Drugs .

Molecular Weight: 236.3 · Solubility in Water: very slight · Solubility in Alcohol: 1 in 500 · Non-proprietary name: Thiacetazone.

Pharmacokinetics

Distribution: Thiacetazone has a plasma protein binding is 95 %.

Elimination: plasma half-life is 12.9 hr, renal excretion is 20 %.

Indications

Thiacetazone is primarily indicated in conditions like Acute leukemia, Tuberculosis.

Contraindications

Thiacetazone is contraindicated in conditions like Hepatic failure.

Dosage

Thiacetazone's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
2.14 mg/kg	2.14 mg/kg	Every 24h	PO	-
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Thiacetazone in overdosage may give rise to further complications which include Diarrhoea , Agranulocytosis , Anemia, Abdominal pain, Vomiting , Anemia , Anemia , Thrombocytopenia , Nausea .

Thiacetazone produces potentially life-threatening effects which include Stevens Johnson syndrome, Toxic epidermal necrolysis. Careful monitoring is needed with proper medical management.

Thiacetazone is known to cause more or less tolerable side effects which are usually transient. These include Ataxia, Blurred vision, Cerebral edema, Deafness , Epilepsy, Salivation , Seizures and convulsions, VertigoX.

Warnings / Precautions

It is very important that your doctor or health care worker check your progress at regular visits. Tell your doctor immediately if blurred vision or loss of vision, with or without eye pain, occurs during treatment . Liver problems may be more likely to occur if you drink alcoholic beverages regularly while you are taking this medicine. Also, the regular use of alcohol may keep this medicine from working properly. Therefore, you should strictly limit the amount of alcoholic beverages you drink while you are taking this medicine.This medicine may cause a very serious rash in any patient, but it occurs more often in patients with human immunodeficiency virus (HIV) infection. If you notice a rash, stop taking this medicine and see your health care worker immediately.

Available Brands

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Multi-Ingredient Combinations

Tabs

150 mg 50 mg

Storage Conditions

Thiacetazone should be stored Tabs.

Drug Classification

1.6.2.4 — Anti-tuberculosis drugs

Manufacturers

Manufacturers of Thiacetazone in Pakistan:

Geofman Wilshire