Thiabendazole

Drug #708

Thiabendazole is a broad spectrum anthelmintic agent. Thiabendazole is a benzimidazole compound. It has vermicidal activity against roundworm, whipworm and hookworm. It also has anti-infalmmatory properties, antipyretic, mild antifungal and scabicidal actions.

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Primary Characteristics

It belongs to Imidazole.

It belongs to Fumarate reductase inhibitor pharmacological group on the basis of mechanism of action and also classified in Anthelmintics pharmacological group.

Molecular Weight: 201.3 · pK_a: 4.7 · Solubility in Water: < 1 in 10000 · Solubility in Alcohol: 1 in 50 · Non-proprietary name: Thiabendazole.

Pharmacokinetics

Absorption: Thiabendazole has an oral bioavailability is 94% (±4%).

Distribution: Thiabendazole has a volume of distribution is 2.76 l/kg.

Elimination: it is metabolised via Hepatic, plasma half-life is 1.17 hr.

Indications

Thiabendazole is primarily indicated in conditions like Helminth infection.

Contraindications

Thiabendazole is contraindicated in conditions like Hypersensitivity to any component of product.

Dosage

Thiabendazole's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
25 mg/kg	25 mg/kg	Every 12h	PO	-
Paediatric Dosage (20kg)
25 mg/kg	25 mg/kg	Every 12h	Oral	-
Neonatal Dosage (3kg)
25 mg/kg	25 mg/kg	Every 12h	Oral	-

Drug Interactions

Unknown4 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Thiabendazole produces potentially life-threatening effects which include Stevens Johnson syndrome, Jaundice . Careful monitoring is needed with proper medical management.

Thiabendazole is known to cause more or less tolerable side effects which are usually transient. These include Anorexia , Blurred vision, Dizziness, Drowsiness, Elevated hepatic transaminases, GI irritation, Leukopenia, Nausea, Paresthesias, Pruritus , Tinnitus, Vomiting .

Warnings / Precautions

Thiabendazole should be used with caution in patients with kidney or liver disease. Patient should observe caution while driving or performing tasks requiring alertness.

Interference in Pathology

Thiabendazole may interfere in the diagnosis of Abnormal LFTs .

Available Brands

None recorded.

Storage Conditions

Thiabendazole should be stored Tab, Susp.

Drug Classification

1.6.1.1 — Intestinal anthelmintics