Tetracosactrin
Also known as: Tetracosactide, Cosyntropin
Tetracosactrin is a synthetic polypeptide. Tetracosactrin is used as a test of adrenal function and for the treatment of inflammatory or degenerative disorders.
Primary Characteristics
Tetracosactrin is also known as Tetracosactide, Cosyntropin.
It is of Synthetic origin and belongs to Polypeptide.
It belongs to ACTH agonist pharmacological group on the basis of mechanism of action. It is also classified under Diagnostic Aids .
Molecular Weight: 2993.5 · Solubility in Water: 1 in 70 · Solubility in Alcohol: insoluble · Non-proprietary name: Tetracosactrin.
Pharmacokinetics
Absorption: Tetracosactrin has an oral bioavailability is 0.5% (±0.5%).
Distribution: Tetracosactrin has a volume of distribution is 0.4 l/kg.
Elimination: plasma half-life is 3 hr, renal excretion is 95 - 100 %.
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Indications
Tetracosactrin is primarily indicated in conditions like Crohn's disease, Investigation of adrenocortical function, Juvenile chronic arthritis, Multiple sclerosis, Osteoarthritis, Rheumatoid arthritis, Ulcerative colitis.
Contraindications
Tetracosactrin is contraindicated in conditions like Asthma, Cushing's syndrome, Heart failure, Peptic ulcer, Psychosis, Infections, Hypersensitivity.
Dosage
Tetracosactrin's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 3.57 ug/kg | 3.57 ug/kg | — | IM | For Once or As Required |
| Paediatric Dosage (20kg) | ||||
| 25 ug/kg | 25 ug/kg | — | Intra Muscular | Single Dose |
| 25 ug/kg | 25 ug/kg | — | Intra Venous | Single Dose |
| Neonatal Dosage (3kg) | ||||
| 36 ug/kg | 36 ug/kg | — | Intramuscular | Single dose |
Drug Interactions
None recorded.
Side Effects
Tetracosactrin in overdosage may give rise to further complications which include Osteoporosis , Diabetes , Growth retardation , Hypertension .
Tetracosactrin produces potentially life-threatening effects which include Anaphylaxis . Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Tetracosactrin are Hyperglycemia.
Tetracosactrin is known to cause more or less tolerable side effects which are usually transient. These include Acne, Bruising, Hirsutism , Menstrual irregularity, Pain , Skin atrophy.
Warnings / Precautions
Interference in Pathology
Tetracosactrin may interfere in the diagnosis of Radioimmunoassay of endogeous ACTH .
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.18.9 — ACTH