Testosterone (Esters)
Testosterone is the primary androgen found in the body. Endogenous testosterone is synthesized by cells in the testis, ovary, and adrenal cortex. Therapeutically, testosterone is used in the management of hypogonadism, either congenital or acquired. Testosterone is also the most effective exogenous androgen for the palliative treatment of carcinoma of the breast in postmenopausal women. Testosterone (Esters) is also used to treat menstrual disorder, breast cancer, postpartum breast pain and for suppression of lactation.<BR>Testosterone undeconoate is one of few new steroids developing during last few years.It is a fatty acid ester of natural androgen,testosterone.
Primary Characteristics
Testosterone (Esters) is also known as Testosterone Undecanoate.
It is of Natural origin and belongs to Steroid.
It belongs to Aldosterone agonist pharmacological group on the basis of mechanism of action. It is also classified under Sex Hormones .
Molecular Weight: 288.4 · Solubility in Water: Insoluble · Solubility in Alcohol: 1 in 6 · Non-proprietary name: Testosterone (Esters).
Pharmacokinetics
Distribution: Testosterone (Esters) has a plasma protein binding is 98 %.
Elimination: it is metabolised via Liver,testis,prostrate, plasma half-life is 1-12 days, renal excretion is 90 %.
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Indications
Testosterone (Esters) is primarily indicated in conditions like Androgen deficiency, Breast cancer, Hormone replacement therapy, Infertility, Menopausal symptoms, Micropenis, Muscle weakness.
Contraindications
Testosterone (Esters) is contraindicated in conditions like Heart failure, Prostatic cancer, Pregnancy.
Dosage
Testosterone (Esters)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 200 mg | 200 mg | — | IM | Maintenance, Every 3rd Week |
| 2 mg | 2 mg | Every 24h | PO | Initially for 2-3 Weeks |
| 80 mg | 80 mg | Every 24h | PO | Maintenance |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Not applicable in paeds | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not applicable in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Testosterone (Esters) in overdosage may give rise to further complications which include Masculinization , Skin rashes , Breathing difficulty.
Testosterone (Esters) produces potentially life-threatening effects which include Hepatic carcinoma. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Testosterone (Esters) are Fluid retension, Polycythemia , Anxiety .
Testosterone (Esters) is known to cause more or less tolerable side effects which are usually transient. These include Acne, Decline in testis size, Depression, Edema, GI disorders, Gynecomastia, Headache, Jaundice , Sleeplessness, Supression of spermatogenesis, Vomiting .
Warnings / Precautions
Interference in Pathology
Testosterone (Esters) may interfere in the diagnosis of Older Urinary Tests for Aldosterone and 17-OH-Corticosteroids , Plasma and Serum Tests for Corticosteroids .
Available Brands
Storage Conditions
Drug Classification
- 1.18.2 — Androgens