Terodiline (HCl)
Terodiline (HCl) relaxes the smooth muscle and used to reduce bladder tone in treatment of urinary frequency and incontinence. Muscle relaxation caused by terodiline, is probably due to its anticholinergic and calcium antagonist activity.
Primary Characteristics
It is of Synthetic origin and belongs to Diphenylproplyamine.
It belongs to Calcium L-channel antagonist pharmacological group on the basis of mechanism of action.
Molecular Weight: 317.9 · pKa: 9.3 · Solubility in Water: slightly · Solubility in Alcohol: very soluble · Non-proprietary name: Terodiline (HCl).
Pharmacokinetics
Absorption: Terodiline (HCl) has an oral bioavailability is 100%, pre-systemic (first-pass) metabolism accounts for 6% (±4%).
Distribution: Terodiline (HCl) has a volume of distribution is 480 litre. plasma protein binding is 85 %.
Elimination: it is metabolised via Hepatic, plasma half-life is 60 hr, renal excretion is 15 %.
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Indications
Terodiline (HCl) is primarily indicated in conditions like Detrusor instability, Diuresis, Urgency and incontinence.
Contraindications
Terodiline (HCl) is contraindicated in conditions like Glucoma, Hepatic disease, Urinary obstruction, GI obstruction.
Dosage
Terodiline (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0.36 mg/kg | 0.36 mg/kg | Every 12h | PO | - |
| Paediatric Dosage (20kg) | ||||
| 0.5 mg/kg | 0.5 mg/kg | Every 12h | Oral | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not used in this age group | |
Drug Interactions
None recorded.
Side Effects
The signs and symptoms that are produced after acute overdosage of Terodiline (HCl) are Bradycardia, Hypotension.
Terodiline (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Constipation , Disturbances of accomodation, Dizziness, Dry mouth, Idosyncratic rashes, Reduced lacrimation, Tachycardia, Tremors, Urinary retensionX.
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.29 — Drugs used in renal, bladder, and prostatic disorders