Azlocillin (Na)

Drug #70

Almost 70 years ago, Alexander Fleming reported his discovery of penicillin in 1929. Chain, Flory and their associates succeeded in producing significant quantities of the first penicillins from the cultures of Penicillium notatum in 1940. Ten years later virtually unlimited quantities of penicillin G were available for clinical use. Azlocillin is a broad spectrum penicillin antibiotic. Penicillin is derived directly or indirectly from strains of fungi of the genus Penicillium and other soil inhibiting fungi grown on special culture media. Penicillins are active against most bacterias especially gram positive pathogens (streptococci, staphylococci, pneumococci), some negative strains (gonococci, meningoccocci), some spirochetes and some fugi. The structure of penicillin consists of a thiazolidine ring connected to a ß lactam ring, which is attached to a side chain.

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Primary Characteristics

It is of Semi Synthetic origin and belongs to Penicillinate.

It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Penicillin pharmacological group.

Molecular Weight: 483.5 · Solubility in Water: soluble · Solubility in Alcohol: slightly soluble · Non-proprietary name: Azlocillin (Na).

Pharmacokinetics

Distribution: Azlocillin (Na) has a volume of distribution is 0.2 l/kg. plasma protein binding is 28%.

Elimination: it is metabolised via 20%, plasma half-life is 1hr, renal excretion is 50-70%.

Indications

Azlocillin (Na) is primarily indicated in conditions like Infection in immunocompromised patients, Meningitis, Urinary tract infection.

Contraindications

Azlocillin (Na) is contraindicated in conditions like Cardiac insufficiency, Hypersensitivity, Hemorrhagic diathesis.

Dosage

Azlocillin (Na)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
28.571 mg/kg	28.571 mg/kg	Every 8h	IV	-
Paediatric Dosage (20kg)
87.5 mg/kg	87.5 mg/kg	Every 8h	Intra Venous	-
Neonatal Dosage (3kg)
87.5 mg/kg	87.5 mg/kg	Every 8h	Intravenous

Drug Interactions

Unknown4 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Azlocillin (Na) in overdosage may give rise to further complications which include Hypokalemia .

The signs and symptoms that are produced after acute overdosage of Azlocillin (Na) are Renal insufficiency, Neurotoxicity, Epileptic seizures.

Azlocillin (Na) is known to cause more or less tolerable side effects which are usually transient. These include Phlebitis .

Warnings / Precautions

It should be used with caution in patients in whom sodium overload could lead to cardiac insufficiency and in patients with renal dysfunction. Use of azlocilline should be avoided during first trimester of pregnancy.

Interference in Pathology

Azlocillin (Na) may interfere in the diagnosis of Invitro assay of aminoglycosides .

Available Brands

None recorded.

Storage Conditions

Azlocillin (Na) should be stored Inj.

Drug Classification

1.6.2.1.1 — Penicillins