Sulindac

Drug #686

Sulindac is NSAID, non-steroidal antinflammatory drug. It also possesses analgesic and antipyretic properties. Sulindac is a sulfoxide and is structurally related to Indomethacin. Sulindac is a prodrug, effective only when Sulindac is converted to a sulfide by liver enzymes. It relieves pain and reduces fever and inflammation.

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Primary Characteristics

It is of Synthetic origin and belongs to NSAID (non-steroidal anti-inflammatory drug).

It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action and also classified in NSAIDs pharmacological group. It is also classified under Analgesics and Anti-inflammatory Agents .

Molecular Weight: 356.42 · pK_a: 4.7 · Solubility in Alcohol: 1 in 30 - 100 · Non-proprietary name: Sulindac.

Pharmacokinetics

Distribution: Sulindac has a plasma protein binding is 93 %.

Elimination: plasma half-life is 7.8 hr, renal excretion is 75 %.

Indications

Sulindac is primarily indicated in conditions like Acute gout, Ankylosing spondylitis, Gout, Nausea and vomiting (palliative care), Osteoarthritis, Pain, Periarticular disorder, Rheumatoid arthritis.

Contraindications

Sulindac is contraindicated in conditions like Peptic ulcer, GI hemorrhage.

Dosage

Sulindac's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
2.14 mg/kg	2.14 mg/kg	Every 24h	PO	-
Paediatric Dosage (20kg)
0 – 0	—	—		SAfety not established
Neonatal Dosage (3kg)
0 – 0	—	—		Should not be used in this age group

Drug Interactions

Unknown2 interactions

1 interaction

Moderate1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Sulindac produces potentially life-threatening effects which include Blood dyscrasias, GI bleeding, Allergic reactions. Careful monitoring is needed with proper medical management.

Sulindac is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Constipation , Dizziness, Drowsiness, Headache, Nausea, Pruritus , Rashes .

Warnings / Precautions

Sulindac should be used with caution in patients with intrinsic coagulation defects and those on anticoagulant therapy. It should be used with caution in patients with compromised cardiac function, hypertension other condition predisposing to fluid retention. It should be used with extra care in the presence of existing controlled infection. Perform periodic auditory function test during chronic therapy. Discontinue drug if skin reaction occurs.

Interference in Pathology

Sulindac may interfere in the diagnosis of Liver Function Test (LFT) .

Available Brands

None recorded.

Storage Conditions

Sulindac should be stored Tab.

Drug Classification

1.2.1.3 — Non steroidal anti-inflammatory drugs (NSAIDs)