DrugInfoSys

Sulfadoxine

Also known as: Sulformethoxine, Sulforthomidine

Drug #685

Sulfadoxine is antibecterial, belongs to sulphonamide. Sulfadoxine is a long-acting drug with a very broad spectrum of activity Sulfadoxine is effective in the treatment of leprosy and in the prevention of malaria.

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Primary Characteristics

Sulfadoxine is also known as Sulformethoxine, Sulforthomidine.

It is of Synthetic origin and belongs to Sulphonamide.

It belongs to Dihyropteroate synthetase inhibitor pharmacological group on the basis of mechanism of action and also classified in Antimalarial Agent pharmacological group.

Molecular Weight: 310.3 · pKa: 6.3 · Solubility in Water: very slightly soluble · Solubility in Alcohol: slightly · Non-proprietary name: Sulfadoxine.

Molecular structure of Sulfadoxine

Pharmacokinetics

Absorption: Sulfadoxine has an oral bioavailability is 60.5% (±9.5%).

Distribution: Sulfadoxine has a volume of distribution is 0.13 l/kg. plasma protein binding is 94%.

Elimination: plasma half-life is 150-200 hr.

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Indications

Sulfadoxine is primarily indicated in conditions like Malaria prophylaxis, Severe falciparum malaria, Toxoplasmosis.

Sulfadoxine is also indicated for secondary conditions like Cholera, Pneumonia.

Contraindications

Sulfadoxine is contraindicated in conditions like Blood dyscrasias, Renal diseases, Hypersensitivity.

Dosage

Sulfadoxine's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
1500 mg1500 mg—POSingle dose in combination with Pyrimethamine 75 mg.
Paediatric Dosage (20kg)
33.33 mg/kg33.33 mg/kg—OralFor Once, Dose for Paeds of 4-12 Yrs.
Neonatal Dosage (3kg)
25 mg/kg25 mg/kg—OralSingle dose

Drug Interactions

Unknown8 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Sulfadoxine in overdosage may give rise to further complications which include Hepatitis , Pneumonitis .

Sulfadoxine produces potentially life-threatening effects which include Mucocutaneous reaction. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Sulfadoxine are Nausea, Convulsions , Excitation , Anorexia , Vomiting, Hematological toxicity.

Sulfadoxine is known to cause more or less tolerable side effects which are usually transient. These include Fatigue, Feeling of fulness, Fever, Headache, Hepatic granulomata, Nausea and vomiting, Orthostatic hypotension, Photosensitivity, Polyneuritis, Pruritus , Rashes , Stomatitis.

Warnings / Precautions

Sulfadoxine should be used only if clearly needed during pregnancy. It should be used with caution in patients with pre-existing blood disorders, anemia, liver disease, kidney disease, severe allergies, asthma or a history of seizures or any allergy, especially to sulfa medications.

Interference in Pathology

Sulfadoxine may interfere in the diagnosis of Complete blood cell count.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Susp
500 mg/5ml

Multi-Ingredient Combinations

Susp
500 mg/5ml
Tabs
50 mg500 mg

Storage Conditions

Sulfadoxine should be stored Tab.

Drug Classification

  1. 1.6.4.3 — Antimalarials

Manufacturers