Spectinomycin (HCl)

Drug #673

Spectinomycin is an aminocyclitol antibiotic derived from Streptomyces spectabilis. Spectinomycin (HCl) is structurally related to aminoglycosides. Spectinomycin lacks amino sugar and glycosidic bonds. Spectinomycin has moderate antibacterial activity against many gram positive and gram negative bacteria but Spectinomycin (HCl) is especially effective against Niesseria gonorrhoeae. Antibiotics require constant drug level in body for therapeutic effect. This is achieveD by taking the medication at regular intervals of time throughout the day and night as prescribed. Spectinomycin (HCl) is important to take the drug for the full time period as prescribed, discontinuation of the therapy may result in ineffective treatment.

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Primary Characteristics

It is of Semi Synthetic origin and belongs to Aminocyclitol Antibiotic.

It belongs to Antibacterial (Proetin synthesis inhibitor) pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.

Molecular Weight: 495.4 · pK_a: 6.88, 8.84 · Solubility in Water: > 1 in 10 · Solubility in Alcohol: < 1 in 10000 · Non-proprietary name: Spectinomycin (HCl) · pH: 4.4 · Isotonic value: 5.66.

Molecular structure of Spectinomycin (HCl)

Pharmacokinetics

Absorption: Spectinomycin (HCl) has an oral bioavailability is 15.5% (±4.5%).

Distribution: Spectinomycin (HCl) has a volume of distribution is 10 - 13.41 litre. plasma protein binding is < 10%.

Elimination: plasma half-life is 1.93 hr, renal excretion is 70 - 100%.

Indications

Spectinomycin (HCl) is primarily indicated in conditions like Cervicitits, Gonorrhoea, Proctitis, Urethritis.

Contraindications

Spectinomycin (HCl) is contraindicated in conditions like Pharyngeal gonorrhoea, Complicated gonococcal infection.

Dosage

Spectinomycin (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
3000 mg	3000 mg	Every 24h	IM	Single Dose
Paediatric Dosage (20kg)
0 – 0	—	—		Not recommended in this age group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown2 interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Spectinomycin (HCl) produces potentially life-threatening effects which include Anaphylaxis . Careful monitoring is needed with proper medical management.

Spectinomycin (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Chills, Dizziness, Fever, Nausea, Urticaria.

Warnings / Precautions

Patients receiving spectinomycin for gonorrhea should be tested for syphilis at the time of treatment and 3 months later because the symptoms of syphilis may be masked or delayed by treatment with spectinomycin. Spectinomycin should be used with caution during pregnancy and in the breast feeding mother. Spectinomycin should be used with caution in children because safe use has not been fully established. Spectinomycin reconstituted with bacteriostatic water containing benzyl alcohol should not be administered to neonates. CNS toxicity in neonates and infants has been blamed on inadvertent administration of benzyl alcohol.

Interference in Pathology

Spectinomycin (HCl) may interfere in the diagnosis of Reduced Haematocrit, Haemoglobin, Creatinine Clearance , Increased Alkaline Phosphatase .

Available Brands

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Single Ingredient

Inj

2 g

Storage Conditions

Spectinomycin (HCl) should be stored Dry Powder for Inj. Inj (reconsitututed soln).

Drug Classification

1.6.2.2.7 — Spectinomycin

Manufacturers

Manufacturers of Spectinomycin (HCl) in Pakistan:

Pfizer