Sotalol (HCl)

Drug #672

Sotalol is beta-adrenergic blocking agent. It has a non-selective beta-blocking activity and similar in action to propranolol. Sotalol (HCl) is a effective antiarrhythmic agent. Administered orally.

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Primary Characteristics

It is of Synthetic origin and belongs to Sulphonamide.

It belongs to Beta adrenergic antagonist pharmacological group on the basis of mechanism of action and also classified in Anti arrhythmic agents pharmacological group.

Molecular Weight: 308.8 · pK_a: 8.3, 9.8 · Solubility in Water: freely · Solubility in Alcohol: Insoluble · Non-proprietary name: Sotalol (HCl).

Pharmacokinetics

Absorption: Sotalol (HCl) has an oral bioavailability is 100%.

Distribution: Sotalol (HCl) has a volume of distribution is 1 - 2 l/kg.

Elimination: plasma half-life is 7 - 18 hr, renal excretion is extensive.

Indications

Sotalol (HCl) is primarily indicated in conditions like Cardiac arrhythmia, Hypertension, Ischaemic heart disease, Life-threatening arrhythmias including ventricular tachyarrhythmias, Prophylaxis of paroxysmal atrial tachycardia or fibrillation.

Sotalol (HCl) is also indicated for secondary conditions like Myocardial infarction, Thyrotoxicosis.

Contraindications

Sotalol (HCl) is contraindicated in conditions like Acidosis, Bronchospasm, Atrioventricular block, Diabetic ketoacidosis.

Dosage

Sotalol (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
1.14 mg/kg	1.14 mg/kg	Every 12h	PO	Initial
3.57 mg/kg	3.57 mg/kg	Every 12h	PO	Maintenance
Paediatric Dosage (20kg)
0 – 0	—	—		Not used in children
Neonatal Dosage (3kg)
0 – 0	—	—		Not used in this age group

Drug Interactions

Unknown20 interactions

3 interactions

Major1 interaction

Moderate1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Sotalol (HCl) in overdosage may give rise to further complications which include Retroperitoneal fibrosis .

Sotalol (HCl) produces potentially life-threatening effects which include Ventricular fibrillation, Ventricular tachycardia, Torsades de pointes. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Sotalol (HCl) are Bradycardia, Cardiac arrhythmias, Hypotension, Cardiac failure.

Sotalol (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Insomnia, Lassitude , Nausea.

Warnings / Precautions

Sotalol should be used only if clearly needed during pregnancy or lactation. It should be used with caution in patients with pre-existing kidney disease, heart disease, lungs disease, asthma, emphysema, thyroid disease, diabetes or if have any allergy.

Interference in Pathology

Sotalol (HCl) may interfere in the diagnosis of Falsely elevated levels of urinary metanephrine.

Available Brands

None recorded.

Storage Conditions

Sotalol (HCl) should be stored Tab.

Drug Classification

1.12.3.1 — Beta blocking agents