Spiramycin
Spiramycin is antibiotic and is used to treat a large variety of bacterial infections, such as respiratory tract infections, middle ear infections, skin infections and urinary tract infections. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular intervals of time throughout the day and night as prescribed. Spiramycin is important to take the drug for the full time period as prescribed, discontinuation of the drug may result in ineffective treatment.
Primary Characteristics
It is of Semi Synthetic origin and belongs to Macrolide Antibiotic.
It belongs to Antibacterial (Proetin synthesis inhibitor) pharmacological group on the basis of mechanism of action and also classified in Macrolide pharmacological group.
Molecular Weight: 843 · pKa: 8.0 · Solubility in Water: 1 in 50 · Solubility in Alcohol: > 1 in 1 · Non-proprietary name: Spiramycin.
Pharmacokinetics
Absorption: Spiramycin has an oral bioavailability is 103%.
Distribution: Spiramycin has a volume of distribution is 383 litre. plasma protein binding is 15%.
Elimination: plasma half-life is 3- 7 hr, renal excretion is > 14%.
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Indications
Spiramycin is primarily indicated in conditions like Depression, Menopausal symptoms, Nerve weakness.
Spiramycin is also indicated for secondary conditions like Fibromyalgia.
Contraindications
Spiramycin is contraindicated in conditions like Hypersensitivity to any component of product.
Dosage
Spiramycin's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 1000 mg | 1000 mg | Every 8h | PO | |
| Paediatric Dosage (20kg) | ||||
| 24.99 mg/kg | 24.99 mg/kg | Every 8h | Oral | |
| Neonatal Dosage (3kg) | ||||
| 24.99 m/kg | 24.99 m/kg | Every 8h | Oral | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Spiramycin in overdosage may give rise to further complications which include Angioedema , Urticaria , Paresthesia, Colitis.
Spiramycin produces potentially life-threatening effects which include Neuromuscular blockage, Ventricular arrhythmias. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Spiramycin are Abdominal pain, Arrhythmias, Headache, Nausea & vomiting.
Spiramycin is known to cause more or less tolerable side effects which are usually transient. These include Anaphylactic shock, Diarrhea.
Warnings / Precautions
Interference in Pathology
Spiramycin may interfere in the diagnosis of Increased transaminases levels.
Available Brands
Storage Conditions
Drug Classification
- 1.6.2.2.4 — Macrolides