Sorbitol
Sorbitol is a six carbon sugar alcohol formed by reduction of the carbonyl group of glucose and occuring naturally in a variety of fruits. Sorbitol is a precursor of fructose in seminal plasma.
Primary Characteristics
It is of Natural origin and belongs to Sugar Alcohol.
It belongs to Nutrients and Vitamins pharmacological group on the basis of mechanism of action and also classified in Parenteral Nutrition pharmacological group.
Molecular Weight: 182.2 · pKa: 13.7 · Solubility in Water: 1 in 0.5 · Solubility in Alcohol: 1 in 25 · Non-proprietary name: Sorbitol · pH: 6.7 · Isotonic value: 5.48.
Pharmacokinetics
Absorption: Sorbitol has an oral bioavailability is 95.5% (±4.5%).
Elimination: it is metabolised via Hepatic, plasma half-life is 20.3 min.
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Indications
Sorbitol is primarily indicated in conditions like Transurethral surgery, Urinary bladder irrigation.
Sorbitol is also indicated for secondary conditions like Constipation.
Contraindications
Sorbitol is contraindicated in conditions like Renal failure, Hepatic failure, Inborn errors of metabolism.
Dosage
Sorbitol's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 30 % | 30 % | — | IV Inf | As Required |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
None recorded.
Side Effects
Sorbitol in overdosage may give rise to further complications which include Urinary retention, Pulmonary congestion, Sinus tachycardia , Seizures , Metabolic acidosis .
Sorbitol produces potentially life-threatening effects which include Increased blood lactate. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Sorbitol are Diuresis, Hyperosmolarity .
Sorbitol is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Blurred vision, Facial flushing, Nausea, SweatingX, Thirst, Vomiting , Xerostomia .
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.26.2.2 — Caloric solutions
- 2.27 — Vitamins, minerals, tonics, and other susbstances